Abstract
INTRODUCTION: Positive social interactions (PSIs) and stable relationships can exert substantial benefits on health. However, patients suffering from depression benefit less from these health-promoting effects. Moreover, relationship quality and even partners' health has been found to be negatively affected by depressive symptomatology, which may result in overall impairments in social functioning of a romantic couple. Psychobiological research indicates that these impairments may be accompanied by a maladaptive regulation of the patient's neuroendocrine response to external stressors. Concerning the improvement of social functioning, first studies showed promising results of "Cognitively Based Compassion Training (CBCT®)". However, randomised trials are still scarce. Previous programmes did not involve participation of the patient's romantic partner. Therefore, the present study aims to investigate whether a CBCT® programme adapted for couples (CBCT®-fC) can improve depressive symptoms, distress, social interaction skills and the neurobiological regulation of stress.
METHODS AND ANALYSIS: Couples with the female partner suffering from depression will be invited to participate in a pre-to-post intervention assessment on two consecutive days, respectively, involving a standardised PSI task, eye-tracking, ECG recordings, saliva-sampling, blood-sampling and questionnaire data. After baseline assessment, participating couples will be randomised to either a 10 week CBCT®-fC or to a treatment as usual control condition. The primary endpoint is the reduction of depressive symptoms measured by the Hamilton Depression Rating Scale. Secondary outcomes encompass self-rated depression (Beck Depression Inventory), attention towards the partners face during PSI (eye tracking), stress-related biomarkers (cortisol, α-amylase, interleukin (IL)-1ß/IL-6, heart rate variability), methylation of oxytocin-receptor-genes and serotonin-transporter-genes and self-ratings of psychological constructs such as relationship quality and empathy.
ETHICS AND DISSEMINATION: Ethical approval has been obtained by the Ethics Committee of the Medical Faculty Heidelberg. Results will be presented in international, peer-reviewed journals and on conferences in the field of clinical psychology and psychiatry.
TRIAL REGISTRATION NUMBER: NCT03080025.
| Original language | English (US) |
|---|---|
| Pages (from-to) | e020448 |
| Journal | BMJ Open |
| Volume | 8 |
| Issue number | 9 |
| DOIs | |
| State | Published - Oct 4 2018 |
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Keywords
- mindfulness- and compassion based intervention
- psychobiological indicators of health
- study protocol
ASJC Scopus subject areas
- Medicine(all)
Cite this
Enhancing Social Interaction in Depression (SIDE study) : protocol of a randomised controlled trial on the effects of a Cognitively Based Compassion Training (CBCT) for couples. / Aguilar-Raab, Corina; Jarczok, Marc N.; Warth, Marco; Stoffel, Martin; Winter, Friederike; Tieck, Maria; Berg, Judith; Negi, Lobsang Tenzin; Harrison, Tim; Pace, Thaddeus Wesley Warren; Ditzen, Beate.
In: BMJ Open, Vol. 8, No. 9, 04.10.2018, p. e020448.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enhancing Social Interaction in Depression (SIDE study)
T2 - protocol of a randomised controlled trial on the effects of a Cognitively Based Compassion Training (CBCT) for couples
AU - Aguilar-Raab, Corina
AU - Jarczok, Marc N.
AU - Warth, Marco
AU - Stoffel, Martin
AU - Winter, Friederike
AU - Tieck, Maria
AU - Berg, Judith
AU - Negi, Lobsang Tenzin
AU - Harrison, Tim
AU - Pace, Thaddeus Wesley Warren
AU - Ditzen, Beate
PY - 2018/10/4
Y1 - 2018/10/4
N2 - INTRODUCTION: Positive social interactions (PSIs) and stable relationships can exert substantial benefits on health. However, patients suffering from depression benefit less from these health-promoting effects. Moreover, relationship quality and even partners' health has been found to be negatively affected by depressive symptomatology, which may result in overall impairments in social functioning of a romantic couple. Psychobiological research indicates that these impairments may be accompanied by a maladaptive regulation of the patient's neuroendocrine response to external stressors. Concerning the improvement of social functioning, first studies showed promising results of "Cognitively Based Compassion Training (CBCT®)". However, randomised trials are still scarce. Previous programmes did not involve participation of the patient's romantic partner. Therefore, the present study aims to investigate whether a CBCT® programme adapted for couples (CBCT®-fC) can improve depressive symptoms, distress, social interaction skills and the neurobiological regulation of stress.METHODS AND ANALYSIS: Couples with the female partner suffering from depression will be invited to participate in a pre-to-post intervention assessment on two consecutive days, respectively, involving a standardised PSI task, eye-tracking, ECG recordings, saliva-sampling, blood-sampling and questionnaire data. After baseline assessment, participating couples will be randomised to either a 10 week CBCT®-fC or to a treatment as usual control condition. The primary endpoint is the reduction of depressive symptoms measured by the Hamilton Depression Rating Scale. Secondary outcomes encompass self-rated depression (Beck Depression Inventory), attention towards the partners face during PSI (eye tracking), stress-related biomarkers (cortisol, α-amylase, interleukin (IL)-1ß/IL-6, heart rate variability), methylation of oxytocin-receptor-genes and serotonin-transporter-genes and self-ratings of psychological constructs such as relationship quality and empathy.ETHICS AND DISSEMINATION: Ethical approval has been obtained by the Ethics Committee of the Medical Faculty Heidelberg. Results will be presented in international, peer-reviewed journals and on conferences in the field of clinical psychology and psychiatry.TRIAL REGISTRATION NUMBER: NCT03080025.
AB - INTRODUCTION: Positive social interactions (PSIs) and stable relationships can exert substantial benefits on health. However, patients suffering from depression benefit less from these health-promoting effects. Moreover, relationship quality and even partners' health has been found to be negatively affected by depressive symptomatology, which may result in overall impairments in social functioning of a romantic couple. Psychobiological research indicates that these impairments may be accompanied by a maladaptive regulation of the patient's neuroendocrine response to external stressors. Concerning the improvement of social functioning, first studies showed promising results of "Cognitively Based Compassion Training (CBCT®)". However, randomised trials are still scarce. Previous programmes did not involve participation of the patient's romantic partner. Therefore, the present study aims to investigate whether a CBCT® programme adapted for couples (CBCT®-fC) can improve depressive symptoms, distress, social interaction skills and the neurobiological regulation of stress.METHODS AND ANALYSIS: Couples with the female partner suffering from depression will be invited to participate in a pre-to-post intervention assessment on two consecutive days, respectively, involving a standardised PSI task, eye-tracking, ECG recordings, saliva-sampling, blood-sampling and questionnaire data. After baseline assessment, participating couples will be randomised to either a 10 week CBCT®-fC or to a treatment as usual control condition. The primary endpoint is the reduction of depressive symptoms measured by the Hamilton Depression Rating Scale. Secondary outcomes encompass self-rated depression (Beck Depression Inventory), attention towards the partners face during PSI (eye tracking), stress-related biomarkers (cortisol, α-amylase, interleukin (IL)-1ß/IL-6, heart rate variability), methylation of oxytocin-receptor-genes and serotonin-transporter-genes and self-ratings of psychological constructs such as relationship quality and empathy.ETHICS AND DISSEMINATION: Ethical approval has been obtained by the Ethics Committee of the Medical Faculty Heidelberg. Results will be presented in international, peer-reviewed journals and on conferences in the field of clinical psychology and psychiatry.TRIAL REGISTRATION NUMBER: NCT03080025.
KW - mindfulness- and compassion based intervention
KW - psychobiological indicators of health
KW - study protocol
UR - http://www.scopus.com/inward/record.url?scp=85054445777&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054445777&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2017-020448
DO - 10.1136/bmjopen-2017-020448
M3 - Article
VL - 8
SP - e020448
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 9
ER -