Ennancement of DMN-induced kidnex tumors by 1,2-dichlorovinylcysteine in swiss-webster mice

S. D. Meadows, A Jay Gandolfi, Raymond B Nagle, J. W. Shively

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

1,2-Dichlorovinylcysteine (DCVC) is known to cause enlarged nuclei in renal proximal tubule epithelium. This study further characterized the cellular changes induced by DCVC. Also a preliminary investigation of the initiator and promoter potential of DCVC was conducted. When given for 4 weeks in drinking water to S-wiss-Webster mice, DCVC (50 or 100 μg/ml) caused a progressive change in renal epithelia which was persistent at 23 weeks. Enlarged nuclei with uneven chromatin dispersal, multiple nucleoli, and irregular nuclear membranes resided in enlarged, abnormally-shaped cells. These changes were resolved by week 50. Mice initiated with dimethylnitrosamine developed renal tumors by week 27. Mice fed DCVC (10 or 50,μg/ml) for 14 weeks following dimethylnitrosamine initiation, had a slightly higher tumor incidence, a higher incidence of invasive tumors, and had multiple renal tumors unlike animals given dimethylnitrosamine alone.

Original languageEnglish (US)
Pages (from-to)307-318
Number of pages12
JournalDrug and Chemical Toxicology
Volume11
Issue number3
DOIs
Publication statusPublished - 1988

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ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Chemical Health and Safety
  • Chemistry(all)

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