Enteric infection meets intestinal function: How bacterial pathogens cause diarrhoea

V. K. Viswanathan, Kim Hodges, Gail Hecht

Research output: Contribution to journalReview article

117 Scopus citations

Abstract

Infectious diarrhoea is a significant contributor to morbidity and mortality worldwide. In bacterium-induced diarrhoea, rapid loss of fluids and electrolytes results from inhibition of the normal absorptive function of the intestine as well as the activation of secretory processes. Advances in the past 10 years in the fields of gastrointestinal physiology, innate immunity and enteric bacterial virulence mechanisms highlight the multifactorial nature of infectious diarrhoea. This Review explores the various mechanisms that contribute to loss of fluids and electrolytes following bacterial infections, and attempts to link these events to specific virulence factors and toxins.

Original languageEnglish (US)
Pages (from-to)110-119
Number of pages10
JournalNature Reviews Microbiology
Volume7
Issue number2
DOIs
StatePublished - Jan 1 2009

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ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

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