Enteric infection meets intestinal function: How bacterial pathogens cause diarrhoea

Virinchipuram Viswanathan, Kim Hodges, Gail Hecht

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Infectious diarrhoea is a significant contributor to morbidity and mortality worldwide. In bacterium-induced diarrhoea, rapid loss of fluids and electrolytes results from inhibition of the normal absorptive function of the intestine as well as the activation of secretory processes. Advances in the past 10 years in the fields of gastrointestinal physiology, innate immunity and enteric bacterial virulence mechanisms highlight the multifactorial nature of infectious diarrhoea. This Review explores the various mechanisms that contribute to loss of fluids and electrolytes following bacterial infections, and attempts to link these events to specific virulence factors and toxins.

Original languageEnglish (US)
Pages (from-to)110-119
Number of pages10
JournalNature Reviews Microbiology
Volume7
Issue number2
DOIs
StatePublished - 2009

Fingerprint

Diarrhea
Electrolytes
Infection
Secretory Pathway
Virulence Factors
Bacterial Infections
Innate Immunity
Intestines
Virulence
Morbidity
Bacteria
Mortality

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Enteric infection meets intestinal function : How bacterial pathogens cause diarrhoea. / Viswanathan, Virinchipuram; Hodges, Kim; Hecht, Gail.

In: Nature Reviews Microbiology, Vol. 7, No. 2, 2009, p. 110-119.

Research output: Contribution to journalArticle

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