Enteropathogens and other factors associated with severe disease in children with acute watery diarrhea in Lima, Peru

Rosa I. Cama, Umesh D. Parashar, David N. Taylor, Thomas Hickey, Dante Figueroa, Ynes R. Ortega, Sofia Romero, Juan Perez, Charles R Sterling, Jon R. Gentsch, Robert H. Gilman, Roger I. Glass

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Abstract

To evaluate enteropathogens and other factors associated with severe disease in children with diarrhea, 381 children <5 years of age with diarrhea and moderate to severe dehydration (in-patients) and 381 age-, sex-, and date-of-visit-matched children, with mild diarrhea (outpatients) presenting to a hospital in Peru, were studied. Rotavirus was detected in 52% of the in- patients and 35% of the out-patients (odds ratio [OR] = 2.3, 95% confidence interval [95% CI] = 1.6-3.2); 95% of the rotaviruses among in-patients were of serotypes G1-G4. The risk of severe diarrhea was particularly great in children who were not exclusively breast-fed in early infancy and who also lacked piped water in their homes (for children with both characteristics OR = 6.8, 95% CI = 3.6-12.8). The high prevalence of rotavirus and its association with severe diarrhea underscores the need for rotavirus vaccines. Interventions to educate mothers and improve access to safe water should augment the impact of rotavirus vaccines in preventing severe diarrhea.

Original languageEnglish (US)
Pages (from-to)1139-1144
Number of pages6
JournalJournal of Infectious Diseases
Volume179
Issue number5
DOIs
Publication statusPublished - 1999

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Cama, R. I., Parashar, U. D., Taylor, D. N., Hickey, T., Figueroa, D., Ortega, Y. R., ... Glass, R. I. (1999). Enteropathogens and other factors associated with severe disease in children with acute watery diarrhea in Lima, Peru. Journal of Infectious Diseases, 179(5), 1139-1144. https://doi.org/10.1086/314701