Enterovirus D68 Antivirals: Past, Present, and Future

Yanmei Hu, Rami Musharrafieh, Madeleine Zheng, Jun Wang

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Enterovirus D68 (EV-D68) is an RNA virus that causes respiratory illnesses mainly in children. In severe cases, it can lead to neurological complications such as acute flaccid myelitis (AFM). EV-D68 belongs to the enterovirus genera of the Picornaviridae family, which also includes many other significant human pathogens such as poliovirus, enterovirus A71, and rhinovirus. There are currently no vaccines or antivirals against EV-D68. In this review, we present the current understanding of the link between EV-D68 and AFM, the mechanism of viral replication, and recent progress in developing EV-D68 antivirals by targeting various viral proteins and host factors that are essential for viral replication. The future directions of EV-D68 antiviral drug discovery and the criteria for drugs to reach clinical trials are also discussed.

Original languageEnglish (US)
Pages (from-to)1572-1586
Number of pages15
JournalACS Infectious Diseases
Volume6
Issue number7
DOIs
StatePublished - Jul 10 2020

Keywords

  • acute flaccid myelitis
  • antiviral
  • enterovirus D68

ASJC Scopus subject areas

  • Infectious Diseases

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