Environmental arsenic exposure and serum matrix metalloproteinase-9

Jefferey L Burgess, Margaret Kurzius-Spencer, Mary Kay O'Rourke, Sally R. Littau, Jason Roberge, Maria Mercedes Meza-Montenegro, Luis Enrique Gutiérrez-Millán, Robin B Harris

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The objective of this study was to evaluate the relationship between environmental arsenic exposure and serum matrix metalloproteinase (MMP)-9, a biomarker associated with cardiovascular disease and cancer. In a cross-sectional study of residents of Arizona, USA (n=215) and Sonora, Mexico (n=163), drinking water was assayed for total arsenic, and daily drinking water arsenic intake was estimated. Urine was speciated for arsenic, and concentrations were adjusted for specific gravity. Serum was analyzed for MMP-9 using ELISA. Mixed model linear regression was used to assess the relation among drinking water arsenic concentration, drinking water arsenic intake, urinary arsenic sum of species (the sum of arsenite, arsenate, monomethylarsonic acid and dimethylarsinic acid), and MMP-9, controlling for autocorrelation within households. Drinking water arsenic concentration and intake were positively associated with MMP-9, both in crude analysis and after adjustment for gender, country/ethnicity, age, body mass index, current smoking, and diabetes. Urinary arsenic sum of species was positively associated with MMP-9 in multivariable analysis only. Using Akaike's Information Criterion, arsenic concentration in drinking water provided a better fitting model of MMP-9 than either urinary arsenic or drinking water arsenic intake. In conclusion, arsenic exposure evaluated using all three exposure metrics was positively associated with MMP-9.

Original languageEnglish (US)
Pages (from-to)163-169
Number of pages7
JournalJournal of Exposure Science and Environmental Epidemiology
Volume23
Issue number2
DOIs
StatePublished - Mar 2013

Fingerprint

Matrix Metalloproteinase 9
Environmental Exposure
Arsenic
Potable water
Drinking Water
Serum
Drinking
Metalloproteases
Cacodylic Acid
Specific Gravity
Acids
Biomarkers
Medical problems
Mexico
Autocorrelation
Linear regression
Density (specific gravity)
Linear Models
Body Mass Index
Cardiovascular Diseases

Keywords

  • arsenic
  • binational study
  • drinking water
  • matrix metalloproteinase-9
  • urine

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Toxicology
  • Epidemiology

Cite this

Environmental arsenic exposure and serum matrix metalloproteinase-9. / Burgess, Jefferey L; Kurzius-Spencer, Margaret; O'Rourke, Mary Kay; Littau, Sally R.; Roberge, Jason; Meza-Montenegro, Maria Mercedes; Gutiérrez-Millán, Luis Enrique; Harris, Robin B.

In: Journal of Exposure Science and Environmental Epidemiology, Vol. 23, No. 2, 03.2013, p. 163-169.

Research output: Contribution to journalArticle

Burgess, Jefferey L ; Kurzius-Spencer, Margaret ; O'Rourke, Mary Kay ; Littau, Sally R. ; Roberge, Jason ; Meza-Montenegro, Maria Mercedes ; Gutiérrez-Millán, Luis Enrique ; Harris, Robin B. / Environmental arsenic exposure and serum matrix metalloproteinase-9. In: Journal of Exposure Science and Environmental Epidemiology. 2013 ; Vol. 23, No. 2. pp. 163-169.
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