Abstract
Exposure to arsenic in drinking water is associated with an increased rate of lung cancer. The objective of this study was to determine whether arsenic exposure at relatively low concentrations (∼20 μg/L) is associated with changes in biomarkers of lung inflammation, as measured by the ratio of sputum metalloproteinase and antiproteinase activity. A total of 73 subjects residing in Ajo and Tucson, Arizona were recruited for this cross-sectional study. Tap water and first morning void urine were analyzed for arsenic. Matrix metalloproteinase 2 (MMP-2), 9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) were measured in induced sputum. Household tap water arsenic levels in Ajo (20.3±3.7 μg/L) were higher than in those Tucson (4.0±2.3 μg/L), as were mean urinary total inorganic arsenic levels (29.1±20.4 and 11.0±12.0 μg/L, respectively). Log-normalized MMP-2, MMP-9, and TIMP-1 concentrations in sputum were not significantly different between towns. However, after adjusting for town, asthma, diabetes, urinary monomethylarsonic acid/inorganic arsenic, and smoking history, total urinary arsenic was negatively associated with MMP-2 and TIMP-1 levels in sputum and positively associated with the ratio of MMP-2/TIMP-1 and MMP-9/TIMP-1 in sputum. Increased sputum proteinase/antiproteinase activity suggests a potential toxic mechanism for low-level arsenic exposure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 283-290 |
| Number of pages | 8 |
| Journal | Environmental Research |
| Volume | 102 |
| Issue number | 3 |
| DOIs | |
| State | Published - Nov 2006 |
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Keywords
- Arsenic
- Lung inflammation
- Matrix metalloproteinase
- MMP-9
- TIMP-1
ASJC Scopus subject areas
- Environmental Science(all)
Cite this
Environmental arsenic exposure and sputum metalloproteinase concentrations. / Josyula, Arun B.; Poplin, Gerald S.; Kurzius-Spencer, Margaret; McClellen, Hannah E.; Kopplin, Michael J.; Stürup, Stefan; Lantz, Robert Clark; Burgess, Jefferey L.
In: Environmental Research, Vol. 102, No. 3, 11.2006, p. 283-290.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Environmental arsenic exposure and sputum metalloproteinase concentrations
AU - Josyula, Arun B.
AU - Poplin, Gerald S.
AU - Kurzius-Spencer, Margaret
AU - McClellen, Hannah E.
AU - Kopplin, Michael J.
AU - Stürup, Stefan
AU - Lantz, Robert Clark
AU - Burgess, Jefferey L
PY - 2006/11
Y1 - 2006/11
N2 - Exposure to arsenic in drinking water is associated with an increased rate of lung cancer. The objective of this study was to determine whether arsenic exposure at relatively low concentrations (∼20 μg/L) is associated with changes in biomarkers of lung inflammation, as measured by the ratio of sputum metalloproteinase and antiproteinase activity. A total of 73 subjects residing in Ajo and Tucson, Arizona were recruited for this cross-sectional study. Tap water and first morning void urine were analyzed for arsenic. Matrix metalloproteinase 2 (MMP-2), 9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) were measured in induced sputum. Household tap water arsenic levels in Ajo (20.3±3.7 μg/L) were higher than in those Tucson (4.0±2.3 μg/L), as were mean urinary total inorganic arsenic levels (29.1±20.4 and 11.0±12.0 μg/L, respectively). Log-normalized MMP-2, MMP-9, and TIMP-1 concentrations in sputum were not significantly different between towns. However, after adjusting for town, asthma, diabetes, urinary monomethylarsonic acid/inorganic arsenic, and smoking history, total urinary arsenic was negatively associated with MMP-2 and TIMP-1 levels in sputum and positively associated with the ratio of MMP-2/TIMP-1 and MMP-9/TIMP-1 in sputum. Increased sputum proteinase/antiproteinase activity suggests a potential toxic mechanism for low-level arsenic exposure.
AB - Exposure to arsenic in drinking water is associated with an increased rate of lung cancer. The objective of this study was to determine whether arsenic exposure at relatively low concentrations (∼20 μg/L) is associated with changes in biomarkers of lung inflammation, as measured by the ratio of sputum metalloproteinase and antiproteinase activity. A total of 73 subjects residing in Ajo and Tucson, Arizona were recruited for this cross-sectional study. Tap water and first morning void urine were analyzed for arsenic. Matrix metalloproteinase 2 (MMP-2), 9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) were measured in induced sputum. Household tap water arsenic levels in Ajo (20.3±3.7 μg/L) were higher than in those Tucson (4.0±2.3 μg/L), as were mean urinary total inorganic arsenic levels (29.1±20.4 and 11.0±12.0 μg/L, respectively). Log-normalized MMP-2, MMP-9, and TIMP-1 concentrations in sputum were not significantly different between towns. However, after adjusting for town, asthma, diabetes, urinary monomethylarsonic acid/inorganic arsenic, and smoking history, total urinary arsenic was negatively associated with MMP-2 and TIMP-1 levels in sputum and positively associated with the ratio of MMP-2/TIMP-1 and MMP-9/TIMP-1 in sputum. Increased sputum proteinase/antiproteinase activity suggests a potential toxic mechanism for low-level arsenic exposure.
KW - Arsenic
KW - Lung inflammation
KW - Matrix metalloproteinase
KW - MMP-9
KW - TIMP-1
UR - http://www.scopus.com/inward/record.url?scp=33746915331&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746915331&partnerID=8YFLogxK
U2 - 10.1016/j.envres.2006.01.003
DO - 10.1016/j.envres.2006.01.003
M3 - Article
C2 - 16487958
AN - SCOPUS:33746915331
VL - 102
SP - 283
EP - 290
JO - Environmental Research
JF - Environmental Research
SN - 0013-9351
IS - 3
ER -