Environmental arsenic exposure and sputum metalloproteinase concentrations

Arun B. Josyula, Gerald S. Poplin, Margaret Kurzius-Spencer, Hannah E. McClellen, Michael J. Kopplin, Stefan Stürup, Robert Clark Lantz, Jefferey L Burgess

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Exposure to arsenic in drinking water is associated with an increased rate of lung cancer. The objective of this study was to determine whether arsenic exposure at relatively low concentrations (∼20 μg/L) is associated with changes in biomarkers of lung inflammation, as measured by the ratio of sputum metalloproteinase and antiproteinase activity. A total of 73 subjects residing in Ajo and Tucson, Arizona were recruited for this cross-sectional study. Tap water and first morning void urine were analyzed for arsenic. Matrix metalloproteinase 2 (MMP-2), 9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) were measured in induced sputum. Household tap water arsenic levels in Ajo (20.3±3.7 μg/L) were higher than in those Tucson (4.0±2.3 μg/L), as were mean urinary total inorganic arsenic levels (29.1±20.4 and 11.0±12.0 μg/L, respectively). Log-normalized MMP-2, MMP-9, and TIMP-1 concentrations in sputum were not significantly different between towns. However, after adjusting for town, asthma, diabetes, urinary monomethylarsonic acid/inorganic arsenic, and smoking history, total urinary arsenic was negatively associated with MMP-2 and TIMP-1 levels in sputum and positively associated with the ratio of MMP-2/TIMP-1 and MMP-9/TIMP-1 in sputum. Increased sputum proteinase/antiproteinase activity suggests a potential toxic mechanism for low-level arsenic exposure.

Original languageEnglish (US)
Pages (from-to)283-290
Number of pages8
JournalEnvironmental Research
Volume102
Issue number3
DOIs
StatePublished - Nov 2006

Fingerprint

Environmental Exposure
Arsenic
Metalloproteases
Sputum
arsenic
Tissue Inhibitor of Metalloproteinase-1
Matrix Metalloproteinase 2
inhibitor
matrix
Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinases
inorganic acid
exposure
Water
diabetes
Poisons
asthma
Matrix Metalloproteinase 9
Biomarkers
Medical problems

Keywords

  • Arsenic
  • Lung inflammation
  • Matrix metalloproteinase
  • MMP-9
  • TIMP-1

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

Environmental arsenic exposure and sputum metalloproteinase concentrations. / Josyula, Arun B.; Poplin, Gerald S.; Kurzius-Spencer, Margaret; McClellen, Hannah E.; Kopplin, Michael J.; Stürup, Stefan; Lantz, Robert Clark; Burgess, Jefferey L.

In: Environmental Research, Vol. 102, No. 3, 11.2006, p. 283-290.

Research output: Contribution to journalArticle

Josyula, Arun B. ; Poplin, Gerald S. ; Kurzius-Spencer, Margaret ; McClellen, Hannah E. ; Kopplin, Michael J. ; Stürup, Stefan ; Lantz, Robert Clark ; Burgess, Jefferey L. / Environmental arsenic exposure and sputum metalloproteinase concentrations. In: Environmental Research. 2006 ; Vol. 102, No. 3. pp. 283-290.
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