Environmental Predictors of Seasonal Influenza Epidemics across Temperate and Tropical Climates

James D. Tamerius, Jeffrey Shaman, Wladmir J. Alonso, Kimberly Bloom-Feshbach, Christopher K. Uejio, Andrew Comrie, Cécile Viboud

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Human influenza infections exhibit a strong seasonal cycle in temperate regions. Recent laboratory and epidemiological evidence suggests that low specific humidity conditions facilitate the airborne survival and transmission of the influenza virus in temperate regions, resulting in annual winter epidemics. However, this relationship is unlikely to account for the epidemiology of influenza in tropical and subtropical regions where epidemics often occur during the rainy season or transmit year-round without a well-defined season. We assessed the role of specific humidity and other local climatic variables on influenza virus seasonality by modeling epidemiological and climatic information from 78 study sites sampled globally. We substantiated that there are two types of environmental conditions associated with seasonal influenza epidemics: "cold-dry" and "humid-rainy". For sites where monthly average specific humidity or temperature decreases below thresholds of approximately 11-12 g/kg and 18-21°C during the year, influenza activity peaks during the cold-dry season (i.e., winter) when specific humidity and temperature are at minimal levels. For sites where specific humidity and temperature do not decrease below these thresholds, seasonal influenza activity is more likely to peak in months when average precipitation totals are maximal and greater than 150 mm per month. These findings provide a simple climate-based model rooted in empirical data that accounts for the diversity of seasonal influenza patterns observed across temperate, subtropical and tropical climates.

Original languageEnglish (US)
Article numbere1003194
JournalPLoS Pathogens
Volume9
Issue number3
DOIs
StatePublished - 2013

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Tropical Climate
Human Influenza
Humidity
Orthomyxoviridae
Temperature
Climate
Epidemiology
Infection

ASJC Scopus subject areas

  • Microbiology
  • Parasitology
  • Virology
  • Immunology
  • Genetics
  • Molecular Biology

Cite this

Tamerius, J. D., Shaman, J., Alonso, W. J., Bloom-Feshbach, K., Uejio, C. K., Comrie, A., & Viboud, C. (2013). Environmental Predictors of Seasonal Influenza Epidemics across Temperate and Tropical Climates. PLoS Pathogens, 9(3), [e1003194]. https://doi.org/10.1371/journal.ppat.1003194

Environmental Predictors of Seasonal Influenza Epidemics across Temperate and Tropical Climates. / Tamerius, James D.; Shaman, Jeffrey; Alonso, Wladmir J.; Bloom-Feshbach, Kimberly; Uejio, Christopher K.; Comrie, Andrew; Viboud, Cécile.

In: PLoS Pathogens, Vol. 9, No. 3, e1003194, 2013.

Research output: Contribution to journalArticle

Tamerius, JD, Shaman, J, Alonso, WJ, Bloom-Feshbach, K, Uejio, CK, Comrie, A & Viboud, C 2013, 'Environmental Predictors of Seasonal Influenza Epidemics across Temperate and Tropical Climates', PLoS Pathogens, vol. 9, no. 3, e1003194. https://doi.org/10.1371/journal.ppat.1003194
Tamerius, James D. ; Shaman, Jeffrey ; Alonso, Wladmir J. ; Bloom-Feshbach, Kimberly ; Uejio, Christopher K. ; Comrie, Andrew ; Viboud, Cécile. / Environmental Predictors of Seasonal Influenza Epidemics across Temperate and Tropical Climates. In: PLoS Pathogens. 2013 ; Vol. 9, No. 3.
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