Environmental, socio-demographic and behavioural determinants of malaria risk in the western Kenyan highlands: A case-control study

Kacey C Ernst, Kim A. Lindblade, David Koech, Peter O. Sumba, Dickens O. Kuwuor, Chandy C. John, Mark L. Wilson

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objective To identify risk factors for uncomplicated malaria in highland areas of East Africa at higher risk of malaria epidemics, in order to design appropriate interventions. Methods Prospective, population-based, case-control study in the Nandi Hills, a highland area of western Kenya, to identify environmental, sociodemographic and behavioural factors associated with clinical malaria. Data were collected using field observation, a structured questionnaire, and a global positioning system device. Results We interviewed 488 cases of slide-confirmed malaria and 980 age-matched controls. Multivariate analyses associated higher malaria risk with living <250 m of a forest [OR = 3.3 (95% CI 1.5, 7.1)], <250 m of a swamp [2.8 (1.3, 5.9)], <200 m of maize fields [2.0 (1.2, 3.4)], in the absence of trees <200 m [1.6 (1.2, 2.2)], on flat land [1.6 (1.2, 2.2)], in houses without ceilings [1.5 (1.1, 2.2)], in houses with a separate kitchen building [1.8 (1.4, 2.3)] and in households where the female household head had no education [1.9 (1.1, 3.1)]. Travelling out of the study site [2.2 (1.2, 4.1)] was also associated with increased risk. Conclusions In this East African highland area, risk of developing uncomplicated malaria was multifactorial with a risk factor profile similar to that in endemic regions. Households within close proximity to forest and swamp borders are at higher risk of malaria and should be included in indoor residual spraying campaigns.

Original languageEnglish (US)
Pages (from-to)1258-1265
Number of pages8
JournalTropical Medicine and International Health
Volume14
Issue number10
DOIs
StatePublished - Oct 2009

Fingerprint

Malaria
Case-Control Studies
Demography
Wetlands
Eastern Africa
Geographic Information Systems
Kenya
Zea mays
Multivariate Analysis
Observation
Education
Equipment and Supplies
Population

Keywords

  • Case-control
  • Environmental
  • Highland malaria
  • Household-level
  • Plasmodium falciparum
  • Risk factors

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Parasitology

Cite this

Environmental, socio-demographic and behavioural determinants of malaria risk in the western Kenyan highlands : A case-control study. / Ernst, Kacey C; Lindblade, Kim A.; Koech, David; Sumba, Peter O.; Kuwuor, Dickens O.; John, Chandy C.; Wilson, Mark L.

In: Tropical Medicine and International Health, Vol. 14, No. 10, 10.2009, p. 1258-1265.

Research output: Contribution to journalArticle

Ernst, Kacey C ; Lindblade, Kim A. ; Koech, David ; Sumba, Peter O. ; Kuwuor, Dickens O. ; John, Chandy C. ; Wilson, Mark L. / Environmental, socio-demographic and behavioural determinants of malaria risk in the western Kenyan highlands : A case-control study. In: Tropical Medicine and International Health. 2009 ; Vol. 14, No. 10. pp. 1258-1265.
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N2 - Objective To identify risk factors for uncomplicated malaria in highland areas of East Africa at higher risk of malaria epidemics, in order to design appropriate interventions. Methods Prospective, population-based, case-control study in the Nandi Hills, a highland area of western Kenya, to identify environmental, sociodemographic and behavioural factors associated with clinical malaria. Data were collected using field observation, a structured questionnaire, and a global positioning system device. Results We interviewed 488 cases of slide-confirmed malaria and 980 age-matched controls. Multivariate analyses associated higher malaria risk with living <250 m of a forest [OR = 3.3 (95% CI 1.5, 7.1)], <250 m of a swamp [2.8 (1.3, 5.9)], <200 m of maize fields [2.0 (1.2, 3.4)], in the absence of trees <200 m [1.6 (1.2, 2.2)], on flat land [1.6 (1.2, 2.2)], in houses without ceilings [1.5 (1.1, 2.2)], in houses with a separate kitchen building [1.8 (1.4, 2.3)] and in households where the female household head had no education [1.9 (1.1, 3.1)]. Travelling out of the study site [2.2 (1.2, 4.1)] was also associated with increased risk. Conclusions In this East African highland area, risk of developing uncomplicated malaria was multifactorial with a risk factor profile similar to that in endemic regions. Households within close proximity to forest and swamp borders are at higher risk of malaria and should be included in indoor residual spraying campaigns.

AB - Objective To identify risk factors for uncomplicated malaria in highland areas of East Africa at higher risk of malaria epidemics, in order to design appropriate interventions. Methods Prospective, population-based, case-control study in the Nandi Hills, a highland area of western Kenya, to identify environmental, sociodemographic and behavioural factors associated with clinical malaria. Data were collected using field observation, a structured questionnaire, and a global positioning system device. Results We interviewed 488 cases of slide-confirmed malaria and 980 age-matched controls. Multivariate analyses associated higher malaria risk with living <250 m of a forest [OR = 3.3 (95% CI 1.5, 7.1)], <250 m of a swamp [2.8 (1.3, 5.9)], <200 m of maize fields [2.0 (1.2, 3.4)], in the absence of trees <200 m [1.6 (1.2, 2.2)], on flat land [1.6 (1.2, 2.2)], in houses without ceilings [1.5 (1.1, 2.2)], in houses with a separate kitchen building [1.8 (1.4, 2.3)] and in households where the female household head had no education [1.9 (1.1, 3.1)]. Travelling out of the study site [2.2 (1.2, 4.1)] was also associated with increased risk. Conclusions In this East African highland area, risk of developing uncomplicated malaria was multifactorial with a risk factor profile similar to that in endemic regions. Households within close proximity to forest and swamp borders are at higher risk of malaria and should be included in indoor residual spraying campaigns.

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KW - Plasmodium falciparum

KW - Risk factors

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