EphB2 SNPs and sporadic prostate cancer risk in African American Men

Christiane M. Robbins, Stanley Hooker, Rick A Kittles, John D. Carpten

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The EphB2 gene has been implicated as a tumor suppressor gene somatically altered in both prostate cancer (PC) and colorectal cancer. We have previously shown an association between an EphB2 germline nonsense variant and risk of familial prostate cancer among African American Men (AAM). Here we set out to test the hypothesis that common variation within the EphB2 locus is associated with increased risk of sporadic PC in AAM. We genotyped a set of 341 single nucleotide polymorphisms (SNPs) encompassing the EphB2 locus, including known and novel coding and noncoding variants, in 490 AA sporadic PC cases and 567 matched controls. Single marker-based logistical regression analyses revealed seven EphB2 SNPs showing statistically significant association with prostate cancer risk in our population. The most significant association was achieved for a novel synonymous coding SNP, TGen-624, (Odds Ratio (OR) = 0.22; 95% Confidence Interval (CI) 0.08-0.66, p = 1×10-5). Two other SNPs also show significant associations toward a protective effect rs10465543 and rs12090415 (p = 1×10-4), OR = 0.49 and 0.7, respectively. Two additional SNPs revealed trends towards an increase in risk of prostate cancer, rs4612601 and rs4263970 (p = 0.001), OR = 1.35 and 1.31, respectively. Furthermore, haplotype analysis revealed low levels of linkage disequilibrium within the region, with two blocks being associated with prostate cancer risk among our population. These data suggest that genetic variation at the EphB2 locus may increase risk of sporadic PC among AAM.

Original languageEnglish (US)
Article numbere19494
JournalPLoS One
Volume6
Issue number5
DOIs
StatePublished - 2011
Externally publishedYes

Fingerprint

prostatic neoplasms
African Americans
Polymorphism
single nucleotide polymorphism
Single Nucleotide Polymorphism
Prostatic Neoplasms
Nucleotides
odds ratio
Odds Ratio
Genes
loci
Linkage Disequilibrium
tumor suppressor genes
Tumor Suppressor Genes
Tumors
Haplotypes
Population
linkage disequilibrium
colorectal neoplasms
Colorectal Neoplasms

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

EphB2 SNPs and sporadic prostate cancer risk in African American Men. / Robbins, Christiane M.; Hooker, Stanley; Kittles, Rick A; Carpten, John D.

In: PLoS One, Vol. 6, No. 5, e19494, 2011.

Research output: Contribution to journalArticle

Robbins, Christiane M. ; Hooker, Stanley ; Kittles, Rick A ; Carpten, John D. / EphB2 SNPs and sporadic prostate cancer risk in African American Men. In: PLoS One. 2011 ; Vol. 6, No. 5.
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