Epidemiologic association between prostatitis and prostate cancer

Leslie K Dennis, Charles F. Lynch, James C. Torner

Research output: Contribution to journalArticle

263 Citations (Scopus)

Abstract

Objectives. To quantify the relationship between prostatitis and prostate cancer by pooling previous epidemiologic studies of this association. Methods. A comprehensive search for articles published through 2000 was performed, blinded reviews of each study were conducted, data were abstracted, and all such studies were pooled. Results. In this meta-analysis, an increased risk was seen among men with a history of prostatitis (odds ratio = 1.6), particularly with population-based case-control studies (odds ratio = 1.8). Increased relative risk estimates were also seen among men with a history of syphilis and a history of gonorrhea. Conclusions. These associations with prostate cancer suggest that infections may represent one mechanism through which prostate cancer develops. However, causality is unclear, because recall bias and detection bias cannot be ruled out. Future cohort studies of prostate cancer should examine sexually transmitted infections, as well as other infections, as potential risk factors.

Original languageEnglish (US)
Pages (from-to)78-83
Number of pages6
JournalUrology
Volume60
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

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Prostatitis
Prostatic Neoplasms
Odds Ratio
Gonorrhea
Syphilis
Sexually Transmitted Diseases
Infection
Causality
Meta-Analysis
Case-Control Studies
Epidemiologic Studies
Cohort Studies
Population

ASJC Scopus subject areas

  • Urology

Cite this

Epidemiologic association between prostatitis and prostate cancer. / Dennis, Leslie K; Lynch, Charles F.; Torner, James C.

In: Urology, Vol. 60, No. 1, 2002, p. 78-83.

Research output: Contribution to journalArticle

Dennis, Leslie K ; Lynch, Charles F. ; Torner, James C. / Epidemiologic association between prostatitis and prostate cancer. In: Urology. 2002 ; Vol. 60, No. 1. pp. 78-83.
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