Epidemiology of physician-diagnosed allergic rhinitis in childhood

Anne L Wright, C. J. Holberg, Fernando Martinez, M. Halonen, Wayne J Morgan, L. M. Taussig

Research output: Contribution to journalArticle

370 Citations (Scopus)

Abstract

Objective. To investigate the natural history of and risk factors for allergic rhinitis in the first 6 years of life. Methods. Parents of 747 healthy children followed from birth completed a questionnaire when the child was 6 years old. Data were obtained regarding physician-diagnosed allergic rhinitis (PDAR), associated symptoms, and age at onset. Risk-factor data were taken from earlier questionnaires, and data regarding immunoglobulin E (IgE) and skin-test reactivity were obtained at age 6. Results. By the age of 6, 42% of children had PDAR. Children whose rhinitis began in the first year of life had more respiratory symptoms at age 6 and were more likely to have a diagnosis of asthma. Early introduction of foods or formula, heavy maternal cigarette smoking in the first year of life, and higher IgE, as well as parental allergic disorders, were associated with early development of rhinitis. Risk factors for PDAR that remained significant in a multivariate model included maternal history of physician-diagnosed allergy (odds ratio: 2.2, 95% confidence interval: 1.35-3.54), asthma in the child (4.06, 2.06- 7.99), and IgE greater than 100 IU/mL at age 6 (1.93, 1.18-3.17). The odds for atopic as opposed to nonatopic PDAR were significantly higher only among those with high IgE and those who had dogs. Conclusion. Allergic rhinitis developing in the first years of life is an early manifestation of an atopic predisposition, which may be triggered by early environmental exposures.

Original languageEnglish (US)
Pages (from-to)895-901
Number of pages7
JournalPediatrics
Volume94
Issue number6 I
StatePublished - 1994

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Epidemiology
Physicians
Immunoglobulin E
Rhinitis
Asthma
Mothers
Environmental Exposure
Skin Tests
Natural History
Age of Onset
Allergic Rhinitis
Hypersensitivity
Parents
Smoking
Odds Ratio
Parturition
Dogs
Confidence Intervals
Food
Surveys and Questionnaires

Keywords

  • atopy
  • epidemiology
  • natural history
  • rhinitis
  • risk factors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Epidemiology of physician-diagnosed allergic rhinitis in childhood. / Wright, Anne L; Holberg, C. J.; Martinez, Fernando; Halonen, M.; Morgan, Wayne J; Taussig, L. M.

In: Pediatrics, Vol. 94, No. 6 I, 1994, p. 895-901.

Research output: Contribution to journalArticle

Wright, AL, Holberg, CJ, Martinez, F, Halonen, M, Morgan, WJ & Taussig, LM 1994, 'Epidemiology of physician-diagnosed allergic rhinitis in childhood', Pediatrics, vol. 94, no. 6 I, pp. 895-901.
Wright, Anne L ; Holberg, C. J. ; Martinez, Fernando ; Halonen, M. ; Morgan, Wayne J ; Taussig, L. M. / Epidemiology of physician-diagnosed allergic rhinitis in childhood. In: Pediatrics. 1994 ; Vol. 94, No. 6 I. pp. 895-901.
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N2 - Objective. To investigate the natural history of and risk factors for allergic rhinitis in the first 6 years of life. Methods. Parents of 747 healthy children followed from birth completed a questionnaire when the child was 6 years old. Data were obtained regarding physician-diagnosed allergic rhinitis (PDAR), associated symptoms, and age at onset. Risk-factor data were taken from earlier questionnaires, and data regarding immunoglobulin E (IgE) and skin-test reactivity were obtained at age 6. Results. By the age of 6, 42% of children had PDAR. Children whose rhinitis began in the first year of life had more respiratory symptoms at age 6 and were more likely to have a diagnosis of asthma. Early introduction of foods or formula, heavy maternal cigarette smoking in the first year of life, and higher IgE, as well as parental allergic disorders, were associated with early development of rhinitis. Risk factors for PDAR that remained significant in a multivariate model included maternal history of physician-diagnosed allergy (odds ratio: 2.2, 95% confidence interval: 1.35-3.54), asthma in the child (4.06, 2.06- 7.99), and IgE greater than 100 IU/mL at age 6 (1.93, 1.18-3.17). The odds for atopic as opposed to nonatopic PDAR were significantly higher only among those with high IgE and those who had dogs. Conclusion. Allergic rhinitis developing in the first years of life is an early manifestation of an atopic predisposition, which may be triggered by early environmental exposures.

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