Epidermal growth factor and transforming growth factor-α mRNA in rat small intestine: In situ hybridization study

Bohuslav Dvořák, Hana Holubec, Albert V. LeBouton, Jean M. Wilson, Otakar Koldovský

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The expression of epidermal growth factor (EGF) and transforming growth factor-α (TGF-α) mRNA in the small intestine of suckling and adult rats was examined by in situ hybridization. EGF mRNA was found mainly in the intestinal crypts in adult rats. Adult rats also exhibited a considerably stronger signal for EGF mRNA in comparison to suckling rats, where the signal was very low or absent. In contrast to EGF, very strong expression of TGF-α mRNA was observed in the small intestine of both adult and suckling rats. These data suggest the differences between the expression of EGF and TGF-α in the developing small intestine.

Original languageEnglish (US)
Pages (from-to)291-295
Number of pages5
JournalFEBS Letters
Volume352
Issue number3
DOIs
StatePublished - Oct 3 1994

Keywords

  • Epidermal growth factor
  • Gastrointestinal tract
  • In situ hybridization
  • Transforming growth factor-α
  • submandibular gland

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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