Epidermal growth factor and transforming growth factor-α mRNA in rat small intestine: In situ hybridization study

Bohuslav Dvořák, Hana Holubec, Albert V. LeBouton, Jean Wilson, Otakar Koldovský

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The expression of epidermal growth factor (EGF) and transforming growth factor-α (TGF-α) mRNA in the small intestine of suckling and adult rats was examined by in situ hybridization. EGF mRNA was found mainly in the intestinal crypts in adult rats. Adult rats also exhibited a considerably stronger signal for EGF mRNA in comparison to suckling rats, where the signal was very low or absent. In contrast to EGF, very strong expression of TGF-α mRNA was observed in the small intestine of both adult and suckling rats. These data suggest the differences between the expression of EGF and TGF-α in the developing small intestine.

Original languageEnglish (US)
Pages (from-to)291-295
Number of pages5
JournalFEBS Letters
Volume352
Issue number3
DOIs
StatePublished - Oct 3 1994

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Transforming Growth Factors
Epidermal Growth Factor
Small Intestine
In Situ Hybridization
Rats
Messenger RNA

Keywords

  • Epidermal growth factor
  • Gastrointestinal tract
  • In situ hybridization
  • submandibular gland
  • Transforming growth factor-α

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Epidermal growth factor and transforming growth factor-α mRNA in rat small intestine : In situ hybridization study. / Dvořák, Bohuslav; Holubec, Hana; LeBouton, Albert V.; Wilson, Jean; Koldovský, Otakar.

In: FEBS Letters, Vol. 352, No. 3, 03.10.1994, p. 291-295.

Research output: Contribution to journalArticle

Dvořák, Bohuslav ; Holubec, Hana ; LeBouton, Albert V. ; Wilson, Jean ; Koldovský, Otakar. / Epidermal growth factor and transforming growth factor-α mRNA in rat small intestine : In situ hybridization study. In: FEBS Letters. 1994 ; Vol. 352, No. 3. pp. 291-295.
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