Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer

Ornella I. Selmin; Micah G. Donovan; Barbara J. Stillwater; Leigh Neumayer; Donato F. Romagnolo

doi:10.3389/fnut.2020.00159

Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer

Ornella I. Selmin, Micah G. Donovan, Barbara J. Stillwater, Leigh Neumayer, Donato F. Romagnolo

Research output: Contribution to journal › Review article › peer-review

Abstract

Triple negative breast cancer (TNBC) represents a highly heterogeneous group of breast cancers, lacking expression of the estrogen (ER) and progesterone (PR) receptors, and human epidermal growth factor receptor 2 (HER2). TNBC are characterized by a high level of mutation and metastasis, poor clinical outcomes and overall survival. Here, we review the epigenetic mechanisms of regulation involved in cell pathways disrupted in TNBC, with particular emphasis on dietary food components that may be exploited for the development of effective strategies for management of TNBC.

Original language	English (US)
Article number	159
Journal	Frontiers in Nutrition
Volume	7
DOIs	https://doi.org/10.3389/fnut.2020.00159
State	Published - Sep 8 2020

Keywords

DNA methylation
dietary bioactive compounds
epigenetic regulation
triple negative breast cancer
tumor suppressor

ASJC Scopus subject areas

Food Science
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

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title = "Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer",

abstract = "Triple negative breast cancer (TNBC) represents a highly heterogeneous group of breast cancers, lacking expression of the estrogen (ER) and progesterone (PR) receptors, and human epidermal growth factor receptor 2 (HER2). TNBC are characterized by a high level of mutation and metastasis, poor clinical outcomes and overall survival. Here, we review the epigenetic mechanisms of regulation involved in cell pathways disrupted in TNBC, with particular emphasis on dietary food components that may be exploited for the development of effective strategies for management of TNBC.",

keywords = "DNA methylation, dietary bioactive compounds, epigenetic regulation, triple negative breast cancer, tumor suppressor",

author = "Selmin, {Ornella I.} and Donovan, {Micah G.} and Stillwater, {Barbara J.} and Leigh Neumayer and Romagnolo, {Donato F.}",

note = "Funding Information: This work was supported by grants from the US Department of Defense Breast Cancer Program (BC134119 and BC142258); Cancer Biology Training Grant (T32CA009213); Arizona Cancer Center CROC Pilot Project and Support Grant (P30CA023074); and USDA-NIFA ARZT-1370460-R23-155.",

year = "2020",

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AU - Selmin, Ornella I.

AU - Donovan, Micah G.

AU - Stillwater, Barbara J.

AU - Neumayer, Leigh

AU - Romagnolo, Donato F.

N1 - Funding Information: This work was supported by grants from the US Department of Defense Breast Cancer Program (BC134119 and BC142258); Cancer Biology Training Grant (T32CA009213); Arizona Cancer Center CROC Pilot Project and Support Grant (P30CA023074); and USDA-NIFA ARZT-1370460-R23-155.

PY - 2020/9/8

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N2 - Triple negative breast cancer (TNBC) represents a highly heterogeneous group of breast cancers, lacking expression of the estrogen (ER) and progesterone (PR) receptors, and human epidermal growth factor receptor 2 (HER2). TNBC are characterized by a high level of mutation and metastasis, poor clinical outcomes and overall survival. Here, we review the epigenetic mechanisms of regulation involved in cell pathways disrupted in TNBC, with particular emphasis on dietary food components that may be exploited for the development of effective strategies for management of TNBC.

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KW - tumor suppressor

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