Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer

Ornella I. Selmin, Micah G. Donovan, Barbara J. Stillwater, Leigh Neumayer, Donato F. Romagnolo

Research output: Contribution to journalReview articlepeer-review

Abstract

Triple negative breast cancer (TNBC) represents a highly heterogeneous group of breast cancers, lacking expression of the estrogen (ER) and progesterone (PR) receptors, and human epidermal growth factor receptor 2 (HER2). TNBC are characterized by a high level of mutation and metastasis, poor clinical outcomes and overall survival. Here, we review the epigenetic mechanisms of regulation involved in cell pathways disrupted in TNBC, with particular emphasis on dietary food components that may be exploited for the development of effective strategies for management of TNBC.

Original languageEnglish (US)
Article number159
JournalFrontiers in Nutrition
Volume7
DOIs
StatePublished - Sep 8 2020

Keywords

  • DNA methylation
  • dietary bioactive compounds
  • epigenetic regulation
  • triple negative breast cancer
  • tumor suppressor

ASJC Scopus subject areas

  • Food Science
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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