TY - JOUR
T1 - Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer
AU - Selmin, Ornella I.
AU - Donovan, Micah G.
AU - Stillwater, Barbara J.
AU - Neumayer, Leigh
AU - Romagnolo, Donato F.
N1 - Funding Information:
This work was supported by grants from the US Department of Defense Breast Cancer Program (BC134119 and BC142258); Cancer Biology Training Grant (T32CA009213); Arizona Cancer Center CROC Pilot Project and Support Grant (P30CA023074); and USDA-NIFA ARZT-1370460-R23-155.
Publisher Copyright:
© Copyright © 2020 Selmin, Donovan, Stillwater, Neumayer and Romagnolo.
PY - 2020/9/8
Y1 - 2020/9/8
N2 - Triple negative breast cancer (TNBC) represents a highly heterogeneous group of breast cancers, lacking expression of the estrogen (ER) and progesterone (PR) receptors, and human epidermal growth factor receptor 2 (HER2). TNBC are characterized by a high level of mutation and metastasis, poor clinical outcomes and overall survival. Here, we review the epigenetic mechanisms of regulation involved in cell pathways disrupted in TNBC, with particular emphasis on dietary food components that may be exploited for the development of effective strategies for management of TNBC.
AB - Triple negative breast cancer (TNBC) represents a highly heterogeneous group of breast cancers, lacking expression of the estrogen (ER) and progesterone (PR) receptors, and human epidermal growth factor receptor 2 (HER2). TNBC are characterized by a high level of mutation and metastasis, poor clinical outcomes and overall survival. Here, we review the epigenetic mechanisms of regulation involved in cell pathways disrupted in TNBC, with particular emphasis on dietary food components that may be exploited for the development of effective strategies for management of TNBC.
KW - DNA methylation
KW - dietary bioactive compounds
KW - epigenetic regulation
KW - triple negative breast cancer
KW - tumor suppressor
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U2 - 10.3389/fnut.2020.00159
DO - 10.3389/fnut.2020.00159
M3 - Review article
AN - SCOPUS:85091439810
VL - 7
JO - Frontiers in Nutrition
JF - Frontiers in Nutrition
SN - 2296-861X
M1 - 159
ER -