Abstract
A purified neurotoxin obtained from the scorpion Leiurus quinquestriatus was used to stimulate epinephrine (E) secretion from the isolated, perfused bovine adrenal gland. In low concentrations values. Cholinergic blockade with hexamethonium and atropine completely blocked E secretion stimulated by either toxin or acetylcholine but not secretion stimulated by potassium chloride. The results suggest that the toxin stimulates E secretion through cholinergic mechanisms either by causing release of acetylcholine from splanchnic nerve endings or by directly activating cholinergic receptors on the adrenal chromaffin cell.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 405-409 |
| Number of pages | 5 |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 46 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1978 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
- Toxicology
Cite this
Epinephrine secretion from the perfused adrenal gland produced by scorpion toxin. / Jacobs, Thomas P.; Johnson, David G; Williams, Robert H.
In: Toxicology and Applied Pharmacology, Vol. 46, No. 2, 1978, p. 405-409.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epinephrine secretion from the perfused adrenal gland produced by scorpion toxin
AU - Jacobs, Thomas P.
AU - Johnson, David G
AU - Williams, Robert H.
PY - 1978
Y1 - 1978
N2 - A purified neurotoxin obtained from the scorpion Leiurus quinquestriatus was used to stimulate epinephrine (E) secretion from the isolated, perfused bovine adrenal gland. In low concentrations values. Cholinergic blockade with hexamethonium and atropine completely blocked E secretion stimulated by either toxin or acetylcholine but not secretion stimulated by potassium chloride. The results suggest that the toxin stimulates E secretion through cholinergic mechanisms either by causing release of acetylcholine from splanchnic nerve endings or by directly activating cholinergic receptors on the adrenal chromaffin cell.
AB - A purified neurotoxin obtained from the scorpion Leiurus quinquestriatus was used to stimulate epinephrine (E) secretion from the isolated, perfused bovine adrenal gland. In low concentrations values. Cholinergic blockade with hexamethonium and atropine completely blocked E secretion stimulated by either toxin or acetylcholine but not secretion stimulated by potassium chloride. The results suggest that the toxin stimulates E secretion through cholinergic mechanisms either by causing release of acetylcholine from splanchnic nerve endings or by directly activating cholinergic receptors on the adrenal chromaffin cell.
UR - http://www.scopus.com/inward/record.url?scp=0018082601&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018082601&partnerID=8YFLogxK
U2 - 10.1016/0041-008X(78)90085-6
DO - 10.1016/0041-008X(78)90085-6
M3 - Article
C2 - 734669
AN - SCOPUS:0018082601
VL - 46
SP - 405
EP - 409
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
SN - 0041-008X
IS - 2
ER -