Epinephrine secretion from the perfused adrenal gland produced by scorpion toxin

Thomas P. Jacobs; David G. Johnson; Robert H. Williams

doi:10.1016/0041-008X(78)90085-6

Epinephrine secretion from the perfused adrenal gland produced by scorpion toxin

Thomas P. Jacobs, David G. Johnson, Robert H. Williams

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A purified neurotoxin obtained from the scorpion Leiurus quinquestriatus was used to stimulate epinephrine (E) secretion from the isolated, perfused bovine adrenal gland. In low concentrations values. Cholinergic blockade with hexamethonium and atropine completely blocked E secretion stimulated by either toxin or acetylcholine but not secretion stimulated by potassium chloride. The results suggest that the toxin stimulates E secretion through cholinergic mechanisms either by causing release of acetylcholine from splanchnic nerve endings or by directly activating cholinergic receptors on the adrenal chromaffin cell.

Original language	English (US)
Pages (from-to)	405-409
Number of pages	5
Journal	Toxicology and Applied Pharmacology
Volume	46
Issue number	2
DOIs	https://doi.org/10.1016/0041-008X(78)90085-6
State	Published - Nov 1978
Externally published	Yes

ASJC Scopus subject areas

Toxicology
Pharmacology

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title = "Epinephrine secretion from the perfused adrenal gland produced by scorpion toxin",

abstract = "A purified neurotoxin obtained from the scorpion Leiurus quinquestriatus was used to stimulate epinephrine (E) secretion from the isolated, perfused bovine adrenal gland. In low concentrations values. Cholinergic blockade with hexamethonium and atropine completely blocked E secretion stimulated by either toxin or acetylcholine but not secretion stimulated by potassium chloride. The results suggest that the toxin stimulates E secretion through cholinergic mechanisms either by causing release of acetylcholine from splanchnic nerve endings or by directly activating cholinergic receptors on the adrenal chromaffin cell.",

author = "Jacobs, {Thomas P.} and Johnson, {David G.} and Williams, {Robert H.}",

note = "Funding Information: This work was supportedb y NIH Grants AM-05020, AM-02456, and AM-17698. Dr. Jacobsw as supportedb y a fellowshipf rom the WashingtonS tate Heart Associationa nd postdoctoral fellowship (1 F03 AM 57009-01)f rom the National Institutes of Health. Dr. Johnsoni s a recipiento f a ResearchC areerD evelopmentA ward AM-70727 from the National Instituteso f Health.",

year = "1978",

month = nov,

doi = "10.1016/0041-008X(78)90085-6",

language = "English (US)",

volume = "46",

pages = "405--409",

journal = "Toxicology and Applied Pharmacology",

issn = "0041-008X",

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T1 - Epinephrine secretion from the perfused adrenal gland produced by scorpion toxin

AU - Jacobs, Thomas P.

AU - Johnson, David G.

AU - Williams, Robert H.

N1 - Funding Information: This work was supportedb y NIH Grants AM-05020, AM-02456, and AM-17698. Dr. Jacobsw as supportedb y a fellowshipf rom the WashingtonS tate Heart Associationa nd postdoctoral fellowship (1 F03 AM 57009-01)f rom the National Institutes of Health. Dr. Johnsoni s a recipiento f a ResearchC areerD evelopmentA ward AM-70727 from the National Instituteso f Health.

PY - 1978/11

Y1 - 1978/11

N2 - A purified neurotoxin obtained from the scorpion Leiurus quinquestriatus was used to stimulate epinephrine (E) secretion from the isolated, perfused bovine adrenal gland. In low concentrations values. Cholinergic blockade with hexamethonium and atropine completely blocked E secretion stimulated by either toxin or acetylcholine but not secretion stimulated by potassium chloride. The results suggest that the toxin stimulates E secretion through cholinergic mechanisms either by causing release of acetylcholine from splanchnic nerve endings or by directly activating cholinergic receptors on the adrenal chromaffin cell.

AB - A purified neurotoxin obtained from the scorpion Leiurus quinquestriatus was used to stimulate epinephrine (E) secretion from the isolated, perfused bovine adrenal gland. In low concentrations values. Cholinergic blockade with hexamethonium and atropine completely blocked E secretion stimulated by either toxin or acetylcholine but not secretion stimulated by potassium chloride. The results suggest that the toxin stimulates E secretion through cholinergic mechanisms either by causing release of acetylcholine from splanchnic nerve endings or by directly activating cholinergic receptors on the adrenal chromaffin cell.

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ER -

Epinephrine secretion from the perfused adrenal gland produced by scorpion toxin

Abstract

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