Epinephrine secretion from the perfused adrenal gland produced by scorpion toxin

Thomas P. Jacobs, David G. Johnson, Robert H. Williams

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A purified neurotoxin obtained from the scorpion Leiurus quinquestriatus was used to stimulate epinephrine (E) secretion from the isolated, perfused bovine adrenal gland. In low concentrations values. Cholinergic blockade with hexamethonium and atropine completely blocked E secretion stimulated by either toxin or acetylcholine but not secretion stimulated by potassium chloride. The results suggest that the toxin stimulates E secretion through cholinergic mechanisms either by causing release of acetylcholine from splanchnic nerve endings or by directly activating cholinergic receptors on the adrenal chromaffin cell.

Original languageEnglish (US)
Pages (from-to)405-409
Number of pages5
JournalToxicology and Applied Pharmacology
Volume46
Issue number2
DOIs
StatePublished - Nov 1978
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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