ErbB signaling in cardiac development and disease

Pablo Sanchez-Soria, Todd D. Camenisch

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

The ErbB family of receptor tyrosine kinases (RTKs) is a family of receptors that allow cells to interact with the extracellular environment and transduce signals to the nucleus that promote differentiation, migration and proliferation necessary for proper heart morphogenesis and function. This review focuses on the role of the ErbB family of receptor tyrosine kinases, and their importance in proper heart morphogenesis, as well as their role in maintenance and function of the adult heart. Studies from transgenic mouse models have shown the importance of ErbB receptors in heart development, and provide insight into potential future therapeutic targets to help reduce congenital heart defect (CHD) mortality rates and prevent disease in adults. Cancer therapeutics have also shed light to the ErbB receptors and signaling network, as undesired side effects have demonstrated their importance in adult cardiomyocytes and prevention of cardiomyopathies. This review will discuss ErbB receptor tyrosine kinases (RTK) in heart development and disease including valve formation and partitioning of a four-chambered heart as well as cardiotoxicity when ErbB signaling is attenuated in adults.

Original languageEnglish (US)
Pages (from-to)929-935
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume21
Issue number9
DOIs
StatePublished - Dec 2010

Keywords

  • Cardiotoxicity
  • ErbB
  • Heart development
  • Heart disease
  • Mouse models
  • Therapeutics

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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