ErbB signaling in cardiac development and disease

Pablo Sanchez-Soria, Todd D Camenisch

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The ErbB family of receptor tyrosine kinases (RTKs) is a family of receptors that allow cells to interact with the extracellular environment and transduce signals to the nucleus that promote differentiation, migration and proliferation necessary for proper heart morphogenesis and function. This review focuses on the role of the ErbB family of receptor tyrosine kinases, and their importance in proper heart morphogenesis, as well as their role in maintenance and function of the adult heart. Studies from transgenic mouse models have shown the importance of ErbB receptors in heart development, and provide insight into potential future therapeutic targets to help reduce congenital heart defect (CHD) mortality rates and prevent disease in adults. Cancer therapeutics have also shed light to the ErbB receptors and signaling network, as undesired side effects have demonstrated their importance in adult cardiomyocytes and prevention of cardiomyopathies. This review will discuss ErbB receptor tyrosine kinases (RTK) in heart development and disease including valve formation and partitioning of a four-chambered heart as well as cardiotoxicity when ErbB signaling is attenuated in adults.

Original languageEnglish (US)
Pages (from-to)929-935
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume21
Issue number9
DOIs
StatePublished - Dec 2010

Fingerprint

Heart Diseases
Protein-Tyrosine Kinases
Morphogenesis
Congenital Heart Defects
Cardiomyopathies
Cardiac Myocytes
Transgenic Mice
Maintenance
ErbB Receptors
Mortality
Therapeutics
Neoplasms

Keywords

  • Cardiotoxicity
  • ErbB
  • Heart development
  • Heart disease
  • Mouse models
  • Therapeutics

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

ErbB signaling in cardiac development and disease. / Sanchez-Soria, Pablo; Camenisch, Todd D.

In: Seminars in Cell and Developmental Biology, Vol. 21, No. 9, 12.2010, p. 929-935.

Research output: Contribution to journalArticle

@article{b4aaf2216ccb47c78254a9ee6f3d9e3b,
title = "ErbB signaling in cardiac development and disease",
abstract = "The ErbB family of receptor tyrosine kinases (RTKs) is a family of receptors that allow cells to interact with the extracellular environment and transduce signals to the nucleus that promote differentiation, migration and proliferation necessary for proper heart morphogenesis and function. This review focuses on the role of the ErbB family of receptor tyrosine kinases, and their importance in proper heart morphogenesis, as well as their role in maintenance and function of the adult heart. Studies from transgenic mouse models have shown the importance of ErbB receptors in heart development, and provide insight into potential future therapeutic targets to help reduce congenital heart defect (CHD) mortality rates and prevent disease in adults. Cancer therapeutics have also shed light to the ErbB receptors and signaling network, as undesired side effects have demonstrated their importance in adult cardiomyocytes and prevention of cardiomyopathies. This review will discuss ErbB receptor tyrosine kinases (RTK) in heart development and disease including valve formation and partitioning of a four-chambered heart as well as cardiotoxicity when ErbB signaling is attenuated in adults.",
keywords = "Cardiotoxicity, ErbB, Heart development, Heart disease, Mouse models, Therapeutics",
author = "Pablo Sanchez-Soria and Camenisch, {Todd D}",
year = "2010",
month = "12",
doi = "10.1016/j.semcdb.2010.09.011",
language = "English (US)",
volume = "21",
pages = "929--935",
journal = "Seminars in Cell and Developmental Biology",
issn = "1084-9521",
publisher = "Academic Press Inc.",
number = "9",

}

TY - JOUR

T1 - ErbB signaling in cardiac development and disease

AU - Sanchez-Soria, Pablo

AU - Camenisch, Todd D

PY - 2010/12

Y1 - 2010/12

N2 - The ErbB family of receptor tyrosine kinases (RTKs) is a family of receptors that allow cells to interact with the extracellular environment and transduce signals to the nucleus that promote differentiation, migration and proliferation necessary for proper heart morphogenesis and function. This review focuses on the role of the ErbB family of receptor tyrosine kinases, and their importance in proper heart morphogenesis, as well as their role in maintenance and function of the adult heart. Studies from transgenic mouse models have shown the importance of ErbB receptors in heart development, and provide insight into potential future therapeutic targets to help reduce congenital heart defect (CHD) mortality rates and prevent disease in adults. Cancer therapeutics have also shed light to the ErbB receptors and signaling network, as undesired side effects have demonstrated their importance in adult cardiomyocytes and prevention of cardiomyopathies. This review will discuss ErbB receptor tyrosine kinases (RTK) in heart development and disease including valve formation and partitioning of a four-chambered heart as well as cardiotoxicity when ErbB signaling is attenuated in adults.

AB - The ErbB family of receptor tyrosine kinases (RTKs) is a family of receptors that allow cells to interact with the extracellular environment and transduce signals to the nucleus that promote differentiation, migration and proliferation necessary for proper heart morphogenesis and function. This review focuses on the role of the ErbB family of receptor tyrosine kinases, and their importance in proper heart morphogenesis, as well as their role in maintenance and function of the adult heart. Studies from transgenic mouse models have shown the importance of ErbB receptors in heart development, and provide insight into potential future therapeutic targets to help reduce congenital heart defect (CHD) mortality rates and prevent disease in adults. Cancer therapeutics have also shed light to the ErbB receptors and signaling network, as undesired side effects have demonstrated their importance in adult cardiomyocytes and prevention of cardiomyopathies. This review will discuss ErbB receptor tyrosine kinases (RTK) in heart development and disease including valve formation and partitioning of a four-chambered heart as well as cardiotoxicity when ErbB signaling is attenuated in adults.

KW - Cardiotoxicity

KW - ErbB

KW - Heart development

KW - Heart disease

KW - Mouse models

KW - Therapeutics

UR - http://www.scopus.com/inward/record.url?scp=78449311535&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78449311535&partnerID=8YFLogxK

U2 - 10.1016/j.semcdb.2010.09.011

DO - 10.1016/j.semcdb.2010.09.011

M3 - Article

C2 - 20933094

AN - SCOPUS:78449311535

VL - 21

SP - 929

EP - 935

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

SN - 1084-9521

IS - 9

ER -