Abstract
Background. This study examines the combined effect of two common genetic alterations, ERG and PTEN, in prostate carcinoma progression. Methods. Prostate tissue from 90 patients having unilateral capsular penetrating lesions, and a contra-lateral organ confined second lesion, were examined by immunohistochemistry for the expression of the TMPRSS2:ERG transformation product ERG and the loss of expression of PTEN, a powerful phosphatase inhibiting the PI3 kinase pathway. Multivariate logistic regression was carried out to analyze the data. Results. After adjusting for Gleason score, the odds of having capsular penetration were 5.19 times higher (P = 0.015) for ERG+/PTEN- group as compared to the wild type (ERG-/PTEN+). Conclusions. This study presents the first evidence that ERG over expression and PTEN deletion is associated with greater risk of capsular penetration. Although further studies are needed, these results have the potential to change clinical assessment for prostate cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1233-1240 |
| Number of pages | 8 |
| Journal | Prostate |
| Volume | 73 |
| Issue number | 11 |
| DOIs | |
| State | Published - Aug 2013 |
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Keywords
- capsular penetration
- ERG
- prostate carcinoma
- PTEN
ASJC Scopus subject areas
- Urology
- Oncology
Cite this
ERG overexpression and PTEN status predict capsular penetration in prostate carcinoma. / Nagle, Raymond B; Algotar, Amit M.; Cortez, Connie C.; Smith, Katherine; Jones, Carol; Sathyanarayana, Ubaradka G.; Yun, Steven; Riley, Janice; Nagy, Dea; Dittamore, Ryan; Dalkin, Bruce; Brosh, Laura; Pestano, Gary.
In: Prostate, Vol. 73, No. 11, 08.2013, p. 1233-1240.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - ERG overexpression and PTEN status predict capsular penetration in prostate carcinoma
AU - Nagle, Raymond B
AU - Algotar, Amit M.
AU - Cortez, Connie C.
AU - Smith, Katherine
AU - Jones, Carol
AU - Sathyanarayana, Ubaradka G.
AU - Yun, Steven
AU - Riley, Janice
AU - Nagy, Dea
AU - Dittamore, Ryan
AU - Dalkin, Bruce
AU - Brosh, Laura
AU - Pestano, Gary
PY - 2013/8
Y1 - 2013/8
N2 - Background. This study examines the combined effect of two common genetic alterations, ERG and PTEN, in prostate carcinoma progression. Methods. Prostate tissue from 90 patients having unilateral capsular penetrating lesions, and a contra-lateral organ confined second lesion, were examined by immunohistochemistry for the expression of the TMPRSS2:ERG transformation product ERG and the loss of expression of PTEN, a powerful phosphatase inhibiting the PI3 kinase pathway. Multivariate logistic regression was carried out to analyze the data. Results. After adjusting for Gleason score, the odds of having capsular penetration were 5.19 times higher (P = 0.015) for ERG+/PTEN- group as compared to the wild type (ERG-/PTEN+). Conclusions. This study presents the first evidence that ERG over expression and PTEN deletion is associated with greater risk of capsular penetration. Although further studies are needed, these results have the potential to change clinical assessment for prostate cancer.
AB - Background. This study examines the combined effect of two common genetic alterations, ERG and PTEN, in prostate carcinoma progression. Methods. Prostate tissue from 90 patients having unilateral capsular penetrating lesions, and a contra-lateral organ confined second lesion, were examined by immunohistochemistry for the expression of the TMPRSS2:ERG transformation product ERG and the loss of expression of PTEN, a powerful phosphatase inhibiting the PI3 kinase pathway. Multivariate logistic regression was carried out to analyze the data. Results. After adjusting for Gleason score, the odds of having capsular penetration were 5.19 times higher (P = 0.015) for ERG+/PTEN- group as compared to the wild type (ERG-/PTEN+). Conclusions. This study presents the first evidence that ERG over expression and PTEN deletion is associated with greater risk of capsular penetration. Although further studies are needed, these results have the potential to change clinical assessment for prostate cancer.
KW - capsular penetration
KW - ERG
KW - prostate carcinoma
KW - PTEN
UR - http://www.scopus.com/inward/record.url?scp=84879419889&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879419889&partnerID=8YFLogxK
U2 - 10.1002/pros.22675
DO - 10.1002/pros.22675
M3 - Article
C2 - 23653096
AN - SCOPUS:84879419889
VL - 73
SP - 1233
EP - 1240
JO - Prostate
JF - Prostate
SN - 0270-4137
IS - 11
ER -