ERG overexpression and PTEN status predict capsular penetration in prostate carcinoma

Raymond B. Nagle; Amit M. Algotar; Connie C. Cortez; Katherine Smith; Carol Jones; Ubaradka G. Sathyanarayana; Steven Yun; Janice Riley; Dea Nagy; Ryan Dittamore; Bruce Dalkin; Laura Brosh; Gary Pestano

doi:10.1002/pros.22675

ERG overexpression and PTEN status predict capsular penetration in prostate carcinoma

Raymond B. Nagle, Amit M. Algotar, Connie C. Cortez, Katherine Smith, Carol Jones, Ubaradka G. Sathyanarayana, Steven Yun, Janice Riley, Dea Nagy, Ryan Dittamore, Bruce Dalkin, Laura Brosh, Gary Pestano

Cancer Center

Research output: Contribution to journal › Article

14 Scopus citations

Abstract

Background. This study examines the combined effect of two common genetic alterations, ERG and PTEN, in prostate carcinoma progression. Methods. Prostate tissue from 90 patients having unilateral capsular penetrating lesions, and a contra-lateral organ confined second lesion, were examined by immunohistochemistry for the expression of the TMPRSS2:ERG transformation product ERG and the loss of expression of PTEN, a powerful phosphatase inhibiting the PI3 kinase pathway. Multivariate logistic regression was carried out to analyze the data. Results. After adjusting for Gleason score, the odds of having capsular penetration were 5.19 times higher (P = 0.015) for ERG+/PTEN- group as compared to the wild type (ERG-/PTEN+). Conclusions. This study presents the first evidence that ERG over expression and PTEN deletion is associated with greater risk of capsular penetration. Although further studies are needed, these results have the potential to change clinical assessment for prostate cancer.

Original language	English (US)
Pages (from-to)	1233-1240
Number of pages	8
Journal	Prostate
Volume	73
Issue number	11
DOIs	https://doi.org/10.1002/pros.22675
State	Published - Aug 2013

Keywords

ERG
PTEN
capsular penetration
prostate carcinoma

ASJC Scopus subject areas

Oncology
Urology

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10.1002/pros.22675

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Nagle, R. B., Algotar, A. M., Cortez, C. C., Smith, K., Jones, C., Sathyanarayana, U. G., Yun, S., Riley, J., Nagy, D., Dittamore, R., Dalkin, B., Brosh, L., & Pestano, G. (2013). ERG overexpression and PTEN status predict capsular penetration in prostate carcinoma. Prostate, 73(11), 1233-1240. https://doi.org/10.1002/pros.22675

ERG overexpression and PTEN status predict capsular penetration in prostate carcinoma. / Nagle, Raymond B.; Algotar, Amit M.; Cortez, Connie C.; Smith, Katherine; Jones, Carol; Sathyanarayana, Ubaradka G.; Yun, Steven; Riley, Janice; Nagy, Dea; Dittamore, Ryan; Dalkin, Bruce; Brosh, Laura; Pestano, Gary.

In: Prostate, Vol. 73, No. 11, 08.2013, p. 1233-1240.

Research output: Contribution to journal › Article

Nagle, Raymond B. ; Algotar, Amit M. ; Cortez, Connie C. ; Smith, Katherine ; Jones, Carol ; Sathyanarayana, Ubaradka G. ; Yun, Steven ; Riley, Janice ; Nagy, Dea ; Dittamore, Ryan ; Dalkin, Bruce ; Brosh, Laura ; Pestano, Gary. / ERG overexpression and PTEN status predict capsular penetration in prostate carcinoma. In: Prostate. 2013 ; Vol. 73, No. 11. pp. 1233-1240.

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abstract = "Background. This study examines the combined effect of two common genetic alterations, ERG and PTEN, in prostate carcinoma progression. Methods. Prostate tissue from 90 patients having unilateral capsular penetrating lesions, and a contra-lateral organ confined second lesion, were examined by immunohistochemistry for the expression of the TMPRSS2:ERG transformation product ERG and the loss of expression of PTEN, a powerful phosphatase inhibiting the PI3 kinase pathway. Multivariate logistic regression was carried out to analyze the data. Results. After adjusting for Gleason score, the odds of having capsular penetration were 5.19 times higher (P = 0.015) for ERG+/PTEN- group as compared to the wild type (ERG-/PTEN+). Conclusions. This study presents the first evidence that ERG over expression and PTEN deletion is associated with greater risk of capsular penetration. Although further studies are needed, these results have the potential to change clinical assessment for prostate cancer.",

keywords = "ERG, PTEN, capsular penetration, prostate carcinoma",

author = "Nagle, {Raymond B.} and Algotar, {Amit M.} and Cortez, {Connie C.} and Katherine Smith and Carol Jones and Sathyanarayana, {Ubaradka G.} and Steven Yun and Janice Riley and Dea Nagy and Ryan Dittamore and Bruce Dalkin and Laura Brosh and Gary Pestano",

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AU - Nagle, Raymond B.

AU - Algotar, Amit M.

AU - Cortez, Connie C.

AU - Smith, Katherine

AU - Jones, Carol

AU - Sathyanarayana, Ubaradka G.

AU - Yun, Steven

AU - Riley, Janice

AU - Nagy, Dea

AU - Dittamore, Ryan

AU - Dalkin, Bruce

AU - Brosh, Laura

AU - Pestano, Gary

PY - 2013/8

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N2 - Background. This study examines the combined effect of two common genetic alterations, ERG and PTEN, in prostate carcinoma progression. Methods. Prostate tissue from 90 patients having unilateral capsular penetrating lesions, and a contra-lateral organ confined second lesion, were examined by immunohistochemistry for the expression of the TMPRSS2:ERG transformation product ERG and the loss of expression of PTEN, a powerful phosphatase inhibiting the PI3 kinase pathway. Multivariate logistic regression was carried out to analyze the data. Results. After adjusting for Gleason score, the odds of having capsular penetration were 5.19 times higher (P = 0.015) for ERG+/PTEN- group as compared to the wild type (ERG-/PTEN+). Conclusions. This study presents the first evidence that ERG over expression and PTEN deletion is associated with greater risk of capsular penetration. Although further studies are needed, these results have the potential to change clinical assessment for prostate cancer.

AB - Background. This study examines the combined effect of two common genetic alterations, ERG and PTEN, in prostate carcinoma progression. Methods. Prostate tissue from 90 patients having unilateral capsular penetrating lesions, and a contra-lateral organ confined second lesion, were examined by immunohistochemistry for the expression of the TMPRSS2:ERG transformation product ERG and the loss of expression of PTEN, a powerful phosphatase inhibiting the PI3 kinase pathway. Multivariate logistic regression was carried out to analyze the data. Results. After adjusting for Gleason score, the odds of having capsular penetration were 5.19 times higher (P = 0.015) for ERG+/PTEN- group as compared to the wild type (ERG-/PTEN+). Conclusions. This study presents the first evidence that ERG over expression and PTEN deletion is associated with greater risk of capsular penetration. Although further studies are needed, these results have the potential to change clinical assessment for prostate cancer.

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