Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity

Qingwen Hu, Donna D. Zhang, Limei Wang, Hongxiang Lou, Dongmei Ren

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Eriodictyol-7- O-glucoside, a flavonoid isolated from Dracocephalum rupestre, is among the most potent free radical scavenger. In the present study, we identified eriodictyol-7- O-glucoside as a novel nuclear factor E2-related factor 2 (Nrf2) activator using a high-throughput cellular screening method. This compound activated Nrf2 signaling pathway and was able to stabilize Nrf2 by delaying Nrf2 degradation, resulting in accumulation of Nrf2 protein and activation of the Nrf2-dependent protective response. Recent studies have suggested that activation of Nrf2 pathway would confer protection against cisplatin-induced toxicity. The protective role of eriodictyol-7- O-glucoside in cisplatin-induced toxicity was investigated in a human renal mesangial cell line, HRMC. Cotreatment of HRMC cells with eriodictyol-7- O-glucoside significantly improved cell survival under cisplatin exposure. These findings demonstrated the feasibility of using natural compounds targeting Nrf2 as a therapeutic approach to subvert the side effects of cisplatin in normal cells.

Original languageEnglish (US)
Pages (from-to)1927-1932
Number of pages6
JournalFood and Chemical Toxicology
Volume50
Issue number6
DOIs
StatePublished - Jun 1 2012

Keywords

  • Activate
  • Cisplatin
  • Eriodictyol-7-O-glucoside
  • Nrf2
  • Toxicity

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Fingerprint Dive into the research topics of 'Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity'. Together they form a unique fingerprint.

  • Cite this