Erlotinib-associated exacerbation of hypothyroidism with pericardial tamponade

Tony Kastoon, Craig S Stump, Stephen P. Thomson, Hussein Yassine

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To report a case of erlotinib-associated exacerbation of hypothyroidism complicated by pericardial tamponade.Methods: We describe the patient's clinical presentation, biochemical workup, and clinical course.Results: Non-small cell lung cancer was diagnosed in a 54-year-old woman. After cisplatin and radiation therapy, she was noted to have subclinical hypothyroidism that did not necessitate treatment. The tyrosine kinase inhibitor erlotinib, 150 mg once daily, was prescribed. Three months later, the patient was documented to have severe hypothyroidism. Levothyroxine was prescribed, but she continued to experience shortness of breath, fatigue, and chest and back pain, which resulted in an emergency department visit. Inpatient workup revealed cardiac tamponade with a large pericardial effusion and a right ventricular diastolic collapse. Pericardiocentesis was performed.Conclusions: This is the first case report linking erlotinib use and thyroid disease.

Original languageEnglish (US)
JournalEndocrine Practice
Volume18
Issue number5
DOIs
StatePublished - Sep 1 2012

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Cardiac Tamponade
Hypothyroidism
Pericardiocentesis
Pericardial Effusion
Thyroid Diseases
Back Pain
Chest Pain
Thyroxine
Non-Small Cell Lung Carcinoma
Dyspnea
Protein-Tyrosine Kinases
Cisplatin
Fatigue
Hospital Emergency Service
Inpatients
Radiotherapy
Erlotinib Hydrochloride
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Erlotinib-associated exacerbation of hypothyroidism with pericardial tamponade. / Kastoon, Tony; Stump, Craig S; Thomson, Stephen P.; Yassine, Hussein.

In: Endocrine Practice, Vol. 18, No. 5, 01.09.2012.

Research output: Contribution to journalArticle

Kastoon, Tony ; Stump, Craig S ; Thomson, Stephen P. ; Yassine, Hussein. / Erlotinib-associated exacerbation of hypothyroidism with pericardial tamponade. In: Endocrine Practice. 2012 ; Vol. 18, No. 5.
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