Erratum: Correction: Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study (PLoS Med (2018) 15:3 (e1002522) DOI: 10.1371/journal.pmed.1002522)

Brant M. Wagener, Parker J. Hu, Joo Yeun Oh, Cilina A. Evans, Jillian R. Richter, Jaideep Honavar, Angela P. Brandon, Judy Creighton, Shannon W. Stephens, Charity Morgan, Randal O. Dull, Marisa B. Marques, Jeffrey D. Kerby, Jean Francois Pittet, Rakesh P. Patel

Research output: Contribution to journalComment/debate

Abstract

There is an error in Panel B of Fig 6 and the associated caption. The authors have provided a corrected Fig 6 and caption here. In the Results, in the subsection "Heme levels in patients after TH and resuscitation", there is an error in the fifth sentence of the first paragraph. The correct sentence is: Fig 6B plots the ratio of Hp/2:hemoglobin and Hpx:free heme. The ratio of Hp/2:hemoglobin was greater than 1 (median = 3.5, IQR 1.1-6.0, p<0.01 by one sample t-test and comparison to a theoretical mean of one), although variance is noted. For hemopexin:free heme, this ratio was lower (median = 0.56, IQR 0.34-0.86) and below one (p<0.01 by one sample t-test and comparison to a theoretical mean of one). In the Discussion, there is an error in the seventh sentence of the eighth paragraph. The correct sentence is: While the absolute concentration of these mediators is important, the relative concentrations of hemoglobin and free heme, compared to Hp and Hpx respectively is likely of greater clinical significance; Hp and Hpx are the endogenous primary defense mechanisms protecting against hemolysis-dependent injury. We show that Hp levels were higher than Hpx, with the Hp:hemoglobin dimer ratio being greater than 1. There is an error in the tab "Fig 6A-6B" of the S1 Data file. The authors have provided a corrected S1 Data file here [Figure Presented].

Original languageEnglish (US)
Article numbere1002991
JournalPLoS Medicine
Volume16
Issue number11
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

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Erythrocyte Transfusion
Heme
Bacterial Infections
Hemoglobins
Hemorrhage
Lung
Information Storage and Retrieval
Wounds and Injuries
Hemopexin
Hemolysis
Resuscitation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Erratum : Correction: Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study (PLoS Med (2018) 15:3 (e1002522) DOI: 10.1371/journal.pmed.1002522). / Wagener, Brant M.; Hu, Parker J.; Oh, Joo Yeun; Evans, Cilina A.; Richter, Jillian R.; Honavar, Jaideep; Brandon, Angela P.; Creighton, Judy; Stephens, Shannon W.; Morgan, Charity; Dull, Randal O.; Marques, Marisa B.; Kerby, Jeffrey D.; Pittet, Jean Francois; Patel, Rakesh P.

In: PLoS Medicine, Vol. 16, No. 11, e1002991, 01.01.2019.

Research output: Contribution to journalComment/debate

Wagener, BM, Hu, PJ, Oh, JY, Evans, CA, Richter, JR, Honavar, J, Brandon, AP, Creighton, J, Stephens, SW, Morgan, C, Dull, RO, Marques, MB, Kerby, JD, Pittet, JF & Patel, RP 2019, 'Erratum: Correction: Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study (PLoS Med (2018) 15:3 (e1002522) DOI: 10.1371/journal.pmed.1002522)', PLoS Medicine, vol. 16, no. 11, e1002991. https://doi.org/10.1371/journal.pmed.1002991
Wagener, Brant M. ; Hu, Parker J. ; Oh, Joo Yeun ; Evans, Cilina A. ; Richter, Jillian R. ; Honavar, Jaideep ; Brandon, Angela P. ; Creighton, Judy ; Stephens, Shannon W. ; Morgan, Charity ; Dull, Randal O. ; Marques, Marisa B. ; Kerby, Jeffrey D. ; Pittet, Jean Francois ; Patel, Rakesh P. / Erratum : Correction: Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study (PLoS Med (2018) 15:3 (e1002522) DOI: 10.1371/journal.pmed.1002522). In: PLoS Medicine. 2019 ; Vol. 16, No. 11.
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abstract = "There is an error in Panel B of Fig 6 and the associated caption. The authors have provided a corrected Fig 6 and caption here. In the Results, in the subsection {"}Heme levels in patients after TH and resuscitation{"}, there is an error in the fifth sentence of the first paragraph. The correct sentence is: Fig 6B plots the ratio of Hp/2:hemoglobin and Hpx:free heme. The ratio of Hp/2:hemoglobin was greater than 1 (median = 3.5, IQR 1.1-6.0, p<0.01 by one sample t-test and comparison to a theoretical mean of one), although variance is noted. For hemopexin:free heme, this ratio was lower (median = 0.56, IQR 0.34-0.86) and below one (p<0.01 by one sample t-test and comparison to a theoretical mean of one). In the Discussion, there is an error in the seventh sentence of the eighth paragraph. The correct sentence is: While the absolute concentration of these mediators is important, the relative concentrations of hemoglobin and free heme, compared to Hp and Hpx respectively is likely of greater clinical significance; Hp and Hpx are the endogenous primary defense mechanisms protecting against hemolysis-dependent injury. We show that Hp levels were higher than Hpx, with the Hp:hemoglobin dimer ratio being greater than 1. There is an error in the tab {"}Fig 6A-6B{"} of the S1 Data file. The authors have provided a corrected S1 Data file here [Figure Presented].",
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T2 - Correction: Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study (PLoS Med (2018) 15:3 (e1002522) DOI: 10.1371/journal.pmed.1002522)

AU - Wagener, Brant M.

AU - Hu, Parker J.

AU - Oh, Joo Yeun

AU - Evans, Cilina A.

AU - Richter, Jillian R.

AU - Honavar, Jaideep

AU - Brandon, Angela P.

AU - Creighton, Judy

AU - Stephens, Shannon W.

AU - Morgan, Charity

AU - Dull, Randal O.

AU - Marques, Marisa B.

AU - Kerby, Jeffrey D.

AU - Pittet, Jean Francois

AU - Patel, Rakesh P.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - There is an error in Panel B of Fig 6 and the associated caption. The authors have provided a corrected Fig 6 and caption here. In the Results, in the subsection "Heme levels in patients after TH and resuscitation", there is an error in the fifth sentence of the first paragraph. The correct sentence is: Fig 6B plots the ratio of Hp/2:hemoglobin and Hpx:free heme. The ratio of Hp/2:hemoglobin was greater than 1 (median = 3.5, IQR 1.1-6.0, p<0.01 by one sample t-test and comparison to a theoretical mean of one), although variance is noted. For hemopexin:free heme, this ratio was lower (median = 0.56, IQR 0.34-0.86) and below one (p<0.01 by one sample t-test and comparison to a theoretical mean of one). In the Discussion, there is an error in the seventh sentence of the eighth paragraph. The correct sentence is: While the absolute concentration of these mediators is important, the relative concentrations of hemoglobin and free heme, compared to Hp and Hpx respectively is likely of greater clinical significance; Hp and Hpx are the endogenous primary defense mechanisms protecting against hemolysis-dependent injury. We show that Hp levels were higher than Hpx, with the Hp:hemoglobin dimer ratio being greater than 1. There is an error in the tab "Fig 6A-6B" of the S1 Data file. The authors have provided a corrected S1 Data file here [Figure Presented].

AB - There is an error in Panel B of Fig 6 and the associated caption. The authors have provided a corrected Fig 6 and caption here. In the Results, in the subsection "Heme levels in patients after TH and resuscitation", there is an error in the fifth sentence of the first paragraph. The correct sentence is: Fig 6B plots the ratio of Hp/2:hemoglobin and Hpx:free heme. The ratio of Hp/2:hemoglobin was greater than 1 (median = 3.5, IQR 1.1-6.0, p<0.01 by one sample t-test and comparison to a theoretical mean of one), although variance is noted. For hemopexin:free heme, this ratio was lower (median = 0.56, IQR 0.34-0.86) and below one (p<0.01 by one sample t-test and comparison to a theoretical mean of one). In the Discussion, there is an error in the seventh sentence of the eighth paragraph. The correct sentence is: While the absolute concentration of these mediators is important, the relative concentrations of hemoglobin and free heme, compared to Hp and Hpx respectively is likely of greater clinical significance; Hp and Hpx are the endogenous primary defense mechanisms protecting against hemolysis-dependent injury. We show that Hp levels were higher than Hpx, with the Hp:hemoglobin dimer ratio being greater than 1. There is an error in the tab "Fig 6A-6B" of the S1 Data file. The authors have provided a corrected S1 Data file here [Figure Presented].

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