Erratum: Feasibility of multimodal multiphoton microscopy to facilitate surgical margin assessment in pancreatic cancer (Appl. Opt. (2020) 59 (4806), 10.1364/AO.399032)

Thu Pham, Bhaskar Banerjee, Benjamin Cromey, Soroush Mehravar, Bethany Skovan, Hao Chen, Khanh Kieu

Research output: Contribution to journalArticlepeer-review

Abstract

Pancreatic cancer is a common cancer with poor odds of survival for the patient, with surgical resection offering the only hope of cure. Current surgical practice is time-consuming and, due to time constraints, does not sample the whole cut surface sufficiently to check for remaining cancer. Although microscopy with hematoxylin and eosin (H&E) stain is the gold standard for microscopic evaluation, multiphoton microscopy (MPM) has emerged as an alternative tool for imaging tissue architecture and cellular morphology without labels. We explored the use of multimodal MPM for the label-free identification of normal and cancerous tissue of the pancreas in a mouse model by comparing the images to H&E microscopy. Our early studies indicate that MPM using second-harmonic generation, third-harmonic generation, and multiphoton excitation of endogenous fluorescent proteins can each contribute to the label-free analysis of the pancreatic surgical margin.

Original languageEnglish (US)
Pages (from-to)G1-G7
JournalApplied optics
Volume59
Issue number18
DOIs
StatePublished - Jun 20 2020

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering

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