Erythrocyte cation metabolism in preeclampsia

James R. Sowers, Michael B. Zemel, Richard A. Bronsteen, Paula C. Zemel, Mary F. Walsh, Paul R Standley, Robert J. Sokol

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

To determine if there are abnormalities in cellular cation regulation in pregnancy-induced hypertension, erythrocyte intracellular levels of calcium, magnesium, sodium, and potassium and circulating parathyroid hormone and "endoxin" were examined in 13 women with pregnancy-induced hypertension and 34 control subjects matched for gestational age (≥35 weeks). Both endoxin and parathyroid hormone levels were higher in patients with pregnancy-induced hypertension than in control subjects (endoxin, 294 ± 34 vs. 210 ± 19 pg/ml, p < 0.05; parathyroid hormone, 0.65 ± 0.05 vs. 0.60 ± 0.03 ng/ml); the increase was significant only for endoxin. Intracellular calcium was higher in the patients with pregnancy-induced hypertension (0.033 ± 0.010 vs. 0.015 ± 0.001 mEq/L, p < 0.05, in the patients with pregnancy-induced hypertension and control patients, respectively) but intracellular sodium, potassium, and magnesium levels were not different. This intracellular calcium elevation may be caused directly by the increase in parathyroid hormone or indirectly by the observed elevation in endoxin. Our data indicate that the observed effect is specific because no changes in intracellular sodium, potassium, or magnesium levels were found.

Original languageEnglish (US)
Pages (from-to)441-445
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume161
Issue number2
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Pregnancy Induced Hypertension
Pre-Eclampsia
Cations
Parathyroid Hormone
Erythrocytes
Magnesium
Potassium
Sodium
Calcium
Gestational Age
digoxin-like factors

Keywords

  • calcium
  • cation metabolism
  • endoxin
  • Preeclampsia

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Sowers, J. R., Zemel, M. B., Bronsteen, R. A., Zemel, P. C., Walsh, M. F., Standley, P. R., & Sokol, R. J. (1989). Erythrocyte cation metabolism in preeclampsia. American Journal of Obstetrics and Gynecology, 161(2), 441-445. https://doi.org/10.1016/0002-9378(89)90539-5

Erythrocyte cation metabolism in preeclampsia. / Sowers, James R.; Zemel, Michael B.; Bronsteen, Richard A.; Zemel, Paula C.; Walsh, Mary F.; Standley, Paul R; Sokol, Robert J.

In: American Journal of Obstetrics and Gynecology, Vol. 161, No. 2, 1989, p. 441-445.

Research output: Contribution to journalArticle

Sowers, JR, Zemel, MB, Bronsteen, RA, Zemel, PC, Walsh, MF, Standley, PR & Sokol, RJ 1989, 'Erythrocyte cation metabolism in preeclampsia', American Journal of Obstetrics and Gynecology, vol. 161, no. 2, pp. 441-445. https://doi.org/10.1016/0002-9378(89)90539-5
Sowers, James R. ; Zemel, Michael B. ; Bronsteen, Richard A. ; Zemel, Paula C. ; Walsh, Mary F. ; Standley, Paul R ; Sokol, Robert J. / Erythrocyte cation metabolism in preeclampsia. In: American Journal of Obstetrics and Gynecology. 1989 ; Vol. 161, No. 2. pp. 441-445.
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