Escalated or suppressed cocaine reward, tegmental BDNF, and accumbal dopamine caused by episodic versus continuous social stress in rats

Klaus A. Miczek, Ella M Nikulina, Akiko Shimamoto, Herbert E. Covington

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Abstract

The neural link between ostensibly aversive stress experiences and intensely rewarding drug taking remains to be delineated. Epidemiological data associate stress and the abuse of various drugs, and experimental data identify the conditions that determine how episodic social stress intensifies the motivation for cocaine and the actual self-administration of cocaine. Two types of social stress have been the focus of experimental study in Long-Evans rats, since they engender divergent changes in drug- or sugar-rewarded behavior and in neuroadaptation. Episodic social defeat stress consists of four brief confrontations between the experimental rat and an aggressive resident rat of the Long-Evans strain over the course of 10 d. Subordination stress involves the continuous exposure to an aggressive resident for 5 weeks, while living in a protective cage within the resident's home cage with brief daily confrontations. These stress experiences result in (1) increased intravenous cocaine self-administration under a fixed ratio schedule with prolonged binge-like access in episodically defeated intruder rats but suppressed cocaine intake by continuously subordinate rats; (2) deteriorated sugar preference and intake and decreased exploratory behavior in subordinate, but not intermittently defeated, rats; and (3) a sensitized dopamine (DA) response in the nucleus accumbens via in vivo microdialysis and increased tegmental brain-derived neural growth factor (BDNF) in episodically defeated rats, whereas the continuously subordinate rats show suppression of the DA and BDNF responses. These divergent neuroadaptations to social stress may represent the substrates for the intensification of cocaine "bingeing" relative to the anhedonia-like deterioration of reward processes during subordination stress.

Original languageEnglish (US)
Pages (from-to)9848-9857
Number of pages10
JournalJournal of Neuroscience
Volume31
Issue number27
DOIs
StatePublished - Jul 6 2011

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Reward
Cocaine
Dopamine
Long Evans Rats
Self Administration
Anhedonia
Exploratory Behavior
Microdialysis
Nucleus Accumbens
Pharmaceutical Preparations
Substance-Related Disorders
brain-derived growth factor
Motivation
Appointments and Schedules

ASJC Scopus subject areas

  • Neuroscience(all)

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Escalated or suppressed cocaine reward, tegmental BDNF, and accumbal dopamine caused by episodic versus continuous social stress in rats. / Miczek, Klaus A.; Nikulina, Ella M; Shimamoto, Akiko; Covington, Herbert E.

In: Journal of Neuroscience, Vol. 31, No. 27, 06.07.2011, p. 9848-9857.

Research output: Contribution to journalArticle

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