Esorubicin in advanced endometrial cancer: an ineffective and potentially toxic therapy - A Southwest Oncology Group study

Jacob B. Green, Stephanie Green, Robert V. O'Toole, David S. Alberts, William A. Nahhas, Darryl L. Wallace

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The Southwest Oncology Group conducted a phase II study of esorubicin treatment in patients with advanced endometrial cancer who had received no prior chemotherapy. Twenty of 31 patients were fully evaluable for response and toxicity. There were no clinical responses to treatment and 60% (12/20) of the patients developed severe or life threatening leukopenia on therapy. One evaluable patient was removed from study after a cumulative dose of 150 mg/M2 due to a reduction in left ventricular ejection fraction on MUGA scan and another developed congestive heart failure several months after discontinuation of treatment. Esorubicin has significant toxicity and limited clinical activity in patients with advanced endometrial cancer.

Original languageEnglish (US)
Pages (from-to)191-193
Number of pages3
JournalInvestigational New Drugs
Volume9
Issue number2
DOIs
StatePublished - May 1991

Keywords

  • cardiac toxicity
  • chemotherapy
  • endometrial cancer
  • esorubicin

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)

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