ESTIMATION OF ENTROPIES OF FUSION OF ORGANIC COMPOUNDS.

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Abstract

The entropy of fusion for many drugs and molecules of intermediate size can be estimated in the following manner: (1) for rigid molecules, DELTA S//f approximately equals 13. 5 eu; (2) for long chain derivatives of such molecules, DELTA S//f approximately equals 13. 5 plus or minus 2. 5(n minus 5) eu, where n is the number of flexible links in the chain. In most cases, these simple rules will provide an estimate of DELTA S//f which is sufficiently accurate to obtain reasonable estimates of ideal solubility.

Original languageEnglish (US)
Pages (from-to)108-111
Number of pages4
JournalIndustrial & Engineering Chemistry, Fundamentals
Volume18
Issue number2
Publication statusPublished - May 1979
Externally publishedYes

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ASJC Scopus subject areas

  • Engineering(all)
  • Polymers and Plastics
  • Environmental Science(all)
  • Chemical Engineering (miscellaneous)

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