Estimation of the aqueous solubility I: Application to organic nonelectrolytes

Neera Jain, Samuel H Yalkowsky

Research output: Contribution to journalArticle

249 Citations (Scopus)

Abstract

The estimation of aqueous solubilities of organic nonelectrolytes by the General Solubility Equation (GSE) as proposed by Valvani and Yalkowsky (1980) is used in this study. The data and assumptions on which the GSE are based are reevaluated, and the equation is revised. The revised GSE is validated on a set of 580 pharmaceutically, environmentally, and industrially relevant nonelectrolytes. The revised equation has a stronger theoretical background and provides a more accurate estimation of aqueous solubility.

Original languageEnglish (US)
Pages (from-to)234-252
Number of pages19
JournalJournal of Pharmaceutical Sciences
Volume90
Issue number2
DOIs
StatePublished - 2001

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Solubility

Keywords

  • Estimation
  • Nonelectrolytes
  • Partitioning
  • Solubility

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science

Cite this

Estimation of the aqueous solubility I : Application to organic nonelectrolytes. / Jain, Neera; Yalkowsky, Samuel H.

In: Journal of Pharmaceutical Sciences, Vol. 90, No. 2, 2001, p. 234-252.

Research output: Contribution to journalArticle

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