Estimation of the effect of NaCl on the solubility of organic compounds in aqueous solutions

Na Ni, Mohamed M. El-Sayed, Tapan Sanghvi, Samuel H Yalkowsky

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The Setschenow constant, K(salt), of a nonelectrolyte in a NaCl solution is shown to be related to the logarithm of its octanol-water partition coefficient, log K(ow), determined by K(salt) = A log K(ow) + B, where K(ow) is the octanol-water partition coefficient of the solute and the coefficients A and B are constants. The values of A and B were empirically determined from literature data for 62 organic compounds and validated for a test set of 15 compounds including several drugs. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)1620-1625
Number of pages6
JournalJournal of Pharmaceutical Sciences
Volume89
Issue number12
DOIs
StatePublished - 2000

Fingerprint

Octanols
Organic compounds
Solubility
Salts
Water
Pharmaceutical Preparations

Keywords

  • Nonelectrolyte
  • Partition coefficient
  • Setschenow constant
  • Sodium chloride
  • Solubility

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science

Cite this

Estimation of the effect of NaCl on the solubility of organic compounds in aqueous solutions. / Ni, Na; El-Sayed, Mohamed M.; Sanghvi, Tapan; Yalkowsky, Samuel H.

In: Journal of Pharmaceutical Sciences, Vol. 89, No. 12, 2000, p. 1620-1625.

Research output: Contribution to journalArticle

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AB - The Setschenow constant, K(salt), of a nonelectrolyte in a NaCl solution is shown to be related to the logarithm of its octanol-water partition coefficient, log K(ow), determined by K(salt) = A log K(ow) + B, where K(ow) is the octanol-water partition coefficient of the solute and the coefficients A and B are constants. The values of A and B were empirically determined from literature data for 62 organic compounds and validated for a test set of 15 compounds including several drugs. (C) 2000 Wiley-Liss, Inc.

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