Estimation of the effect of NaCl on the solubility of organic compounds in aqueous solutions

Na Ni, Mohamed M. El-Sayed, Tapan Sanghvi, Samuel H. Yalkowsky

Research output: Contribution to journalArticle

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The Setschenow constant, K(salt), of a nonelectrolyte in a NaCl solution is shown to be related to the logarithm of its octanol-water partition coefficient, log K(ow), determined by K(salt) = A log K(ow) + B, where K(ow) is the octanol-water partition coefficient of the solute and the coefficients A and B are constants. The values of A and B were empirically determined from literature data for 62 organic compounds and validated for a test set of 15 compounds including several drugs. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)1620-1625
Number of pages6
JournalJournal of pharmaceutical sciences
Issue number12
StatePublished - Jan 1 2000



  • Nonelectrolyte
  • Partition coefficient
  • Setschenow constant
  • Sodium chloride
  • Solubility

ASJC Scopus subject areas

  • Pharmaceutical Science

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