Estimation of the ideal solubility (crystal-liquid fugacity ratio) of organic compounds

Research output: Contribution to journalShort survey

18 Scopus citations

Abstract

Melting point, entropy of melting and heat capacity of melting are required for the calculation of the ideal solubility of a solid solute via the Clausius-Clapyron equation. This article reviews the published approximations of estimating entropy and heat capacity of melting. By comparing the available experimental results to calculated values the authors attempt to identify the best estimation of the ideal solubility and crystal-liquid fugacity ratio for organic compounds.

Original languageEnglish (US)
Pages (from-to)1100-1106
Number of pages7
JournalJournal of pharmaceutical sciences
Volume99
Issue number3
DOIs
StatePublished - Mar 2010

Keywords

  • Crystallization
  • Crystals
  • Solid state
  • Solubility
  • Thermodynamics

ASJC Scopus subject areas

  • Pharmaceutical Science

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