Abstract
It is now well established that estrogens can influence a panoply of physiological and behavioral functions. In many instances, the effects of estrogens are mediated by the 'classical' actions of two different estrogen receptors (ERs), ERα or ERβ. ERα and ERβ appear to have opposing actions in the control of stress responses and modulate different neurotransmitter or neuropeptide systems. Studies elucidating the molecular mechanisms for such regulatory processes are currently in progress. Furthermore, the use of ERα and ERβ knockout mouse lines has allowed the exploration of the importance of these receptors in behavioral responses such as anxiety-like and depressive-like behaviors. This review examines some of the recent advances in our knowledge of hormonal control of neuroendocrine and behavioral responses to stress and underscore the importance of these receptors as future therapeutic targets for control of stress-related signaling pathways.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 111-118 |
| Number of pages | 8 |
| Journal | Neuroendocrinology |
| Volume | 96 |
| Issue number | 2 |
| DOIs | |
| State | Published - Sep 2012 |
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Keywords
- Anxiety
- Behavior
- Estradiol
- Hypothalamus
- Pituitary
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Endocrine and Autonomic Systems
- Cellular and Molecular Neuroscience
Cite this
Estrogen receptors and the regulation of neural stress responses. / Handa, Robert J; Mani, Shaila K.; Uht, Rosalie M.
In: Neuroendocrinology, Vol. 96, No. 2, 09.2012, p. 111-118.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Estrogen receptors and the regulation of neural stress responses
AU - Handa, Robert J
AU - Mani, Shaila K.
AU - Uht, Rosalie M.
PY - 2012/9
Y1 - 2012/9
N2 - It is now well established that estrogens can influence a panoply of physiological and behavioral functions. In many instances, the effects of estrogens are mediated by the 'classical' actions of two different estrogen receptors (ERs), ERα or ERβ. ERα and ERβ appear to have opposing actions in the control of stress responses and modulate different neurotransmitter or neuropeptide systems. Studies elucidating the molecular mechanisms for such regulatory processes are currently in progress. Furthermore, the use of ERα and ERβ knockout mouse lines has allowed the exploration of the importance of these receptors in behavioral responses such as anxiety-like and depressive-like behaviors. This review examines some of the recent advances in our knowledge of hormonal control of neuroendocrine and behavioral responses to stress and underscore the importance of these receptors as future therapeutic targets for control of stress-related signaling pathways.
AB - It is now well established that estrogens can influence a panoply of physiological and behavioral functions. In many instances, the effects of estrogens are mediated by the 'classical' actions of two different estrogen receptors (ERs), ERα or ERβ. ERα and ERβ appear to have opposing actions in the control of stress responses and modulate different neurotransmitter or neuropeptide systems. Studies elucidating the molecular mechanisms for such regulatory processes are currently in progress. Furthermore, the use of ERα and ERβ knockout mouse lines has allowed the exploration of the importance of these receptors in behavioral responses such as anxiety-like and depressive-like behaviors. This review examines some of the recent advances in our knowledge of hormonal control of neuroendocrine and behavioral responses to stress and underscore the importance of these receptors as future therapeutic targets for control of stress-related signaling pathways.
KW - Anxiety
KW - Behavior
KW - Estradiol
KW - Hypothalamus
KW - Pituitary
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UR - http://www.scopus.com/inward/citedby.url?scp=84866563308&partnerID=8YFLogxK
U2 - 10.1159/000338397
DO - 10.1159/000338397
M3 - Article
C2 - 22538291
AN - SCOPUS:84866563308
VL - 96
SP - 111
EP - 118
JO - Neuroendocrinology
JF - Neuroendocrinology
SN - 0028-3835
IS - 2
ER -