Ethanol, immune responses, and murine AIDS: The role of vitamin E as an immunostimulant and antioxidant

Yuejian Wang, Ronald R Watson

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Excessive alcohol consumption is a major health problem in the United States. Prolonged consumption of alcohol results in alterations of immune responses, ultimately manifested by increasing susceptibility to infectious agents. Such changes can be due to the direct effects of alcohol or its metabolites on immune cells, as well as to nutritional deficiency, oxidative stress, and neutrophil dysfunctions. This ETOH-induced immunosuppression could be a potential cofactor in the progression to AIDS. As vitamin E supplementation has been associated with enhancement of immune response and improvement of host defense, it may provide a useful therapeutic approach for treatment of alcoholics to improve host defense. This article is a review of alcohol-related immunosuppression as a possible cofactor in the development of AIDS, and vitamin E-related immunoenhancing roles in animals and humans, showing why vitamin E supplementation could be used as a useful adjunct agent in alcoholics' treatment. Since there is little information available regarding nutritional therapy with alcohol users, our purpose is to provide evidence from animal models of the potential therapeutic role of vitamin E supplementation in the treatment of alcoholics.

Original languageEnglish (US)
Pages (from-to)75-84
Number of pages10
JournalAlcohol
Volume11
Issue number2
DOIs
StatePublished - 1994

Fingerprint

Murine Acquired Immunodeficiency Syndrome
Immunologic Adjuvants
Vitamin E
AIDS
Ethanol
Antioxidants
alcohol
Alcohols
alcoholism
Alcoholics
animal
Animals
Alcohol Drinking
Immunosuppression
Acquired Immunodeficiency Syndrome
Therapeutics
available information
alcohol consumption
Oxidative stress
Medical problems

Keywords

  • Alcohol
  • Immune response
  • Murine AIDS
  • Neutrophil
  • Nutritional status
  • Oxidative stress
  • Vitamin E

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Neuroscience(all)
  • Behavioral Neuroscience
  • Toxicology
  • Health(social science)

Cite this

Ethanol, immune responses, and murine AIDS : The role of vitamin E as an immunostimulant and antioxidant. / Wang, Yuejian; Watson, Ronald R.

In: Alcohol, Vol. 11, No. 2, 1994, p. 75-84.

Research output: Contribution to journalArticle

@article{32d67c0036b54d62b25b2093f60bab64,
title = "Ethanol, immune responses, and murine AIDS: The role of vitamin E as an immunostimulant and antioxidant",
abstract = "Excessive alcohol consumption is a major health problem in the United States. Prolonged consumption of alcohol results in alterations of immune responses, ultimately manifested by increasing susceptibility to infectious agents. Such changes can be due to the direct effects of alcohol or its metabolites on immune cells, as well as to nutritional deficiency, oxidative stress, and neutrophil dysfunctions. This ETOH-induced immunosuppression could be a potential cofactor in the progression to AIDS. As vitamin E supplementation has been associated with enhancement of immune response and improvement of host defense, it may provide a useful therapeutic approach for treatment of alcoholics to improve host defense. This article is a review of alcohol-related immunosuppression as a possible cofactor in the development of AIDS, and vitamin E-related immunoenhancing roles in animals and humans, showing why vitamin E supplementation could be used as a useful adjunct agent in alcoholics' treatment. Since there is little information available regarding nutritional therapy with alcohol users, our purpose is to provide evidence from animal models of the potential therapeutic role of vitamin E supplementation in the treatment of alcoholics.",
keywords = "Alcohol, Immune response, Murine AIDS, Neutrophil, Nutritional status, Oxidative stress, Vitamin E",
author = "Yuejian Wang and Watson, {Ronald R}",
year = "1994",
doi = "10.1016/0741-8329(94)90047-7",
language = "English (US)",
volume = "11",
pages = "75--84",
journal = "Alcohol",
issn = "0741-8329",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Ethanol, immune responses, and murine AIDS

T2 - The role of vitamin E as an immunostimulant and antioxidant

AU - Wang, Yuejian

AU - Watson, Ronald R

PY - 1994

Y1 - 1994

N2 - Excessive alcohol consumption is a major health problem in the United States. Prolonged consumption of alcohol results in alterations of immune responses, ultimately manifested by increasing susceptibility to infectious agents. Such changes can be due to the direct effects of alcohol or its metabolites on immune cells, as well as to nutritional deficiency, oxidative stress, and neutrophil dysfunctions. This ETOH-induced immunosuppression could be a potential cofactor in the progression to AIDS. As vitamin E supplementation has been associated with enhancement of immune response and improvement of host defense, it may provide a useful therapeutic approach for treatment of alcoholics to improve host defense. This article is a review of alcohol-related immunosuppression as a possible cofactor in the development of AIDS, and vitamin E-related immunoenhancing roles in animals and humans, showing why vitamin E supplementation could be used as a useful adjunct agent in alcoholics' treatment. Since there is little information available regarding nutritional therapy with alcohol users, our purpose is to provide evidence from animal models of the potential therapeutic role of vitamin E supplementation in the treatment of alcoholics.

AB - Excessive alcohol consumption is a major health problem in the United States. Prolonged consumption of alcohol results in alterations of immune responses, ultimately manifested by increasing susceptibility to infectious agents. Such changes can be due to the direct effects of alcohol or its metabolites on immune cells, as well as to nutritional deficiency, oxidative stress, and neutrophil dysfunctions. This ETOH-induced immunosuppression could be a potential cofactor in the progression to AIDS. As vitamin E supplementation has been associated with enhancement of immune response and improvement of host defense, it may provide a useful therapeutic approach for treatment of alcoholics to improve host defense. This article is a review of alcohol-related immunosuppression as a possible cofactor in the development of AIDS, and vitamin E-related immunoenhancing roles in animals and humans, showing why vitamin E supplementation could be used as a useful adjunct agent in alcoholics' treatment. Since there is little information available regarding nutritional therapy with alcohol users, our purpose is to provide evidence from animal models of the potential therapeutic role of vitamin E supplementation in the treatment of alcoholics.

KW - Alcohol

KW - Immune response

KW - Murine AIDS

KW - Neutrophil

KW - Nutritional status

KW - Oxidative stress

KW - Vitamin E

UR - http://www.scopus.com/inward/record.url?scp=0028274745&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028274745&partnerID=8YFLogxK

U2 - 10.1016/0741-8329(94)90047-7

DO - 10.1016/0741-8329(94)90047-7

M3 - Article

C2 - 8204206

AN - SCOPUS:0028274745

VL - 11

SP - 75

EP - 84

JO - Alcohol

JF - Alcohol

SN - 0741-8329

IS - 2

ER -