Ethnic differences in coronary calcification: The Multi-Ethnic Study of Atherosclerosis (MESA)

Diane E. Bild, Robert Detrano, Do Peterson, Alan Guerci, Kiang Liu, Eyal Shahar, Pamela Ouyang, Sharon Jackson, Mohammed F. Saad

Research output: Contribution to journalArticle

474 Citations (Scopus)

Abstract

Background - There is substantial evidence that coronary calcification, a marker for the presence and quantity of coronary atherosclerosis, is higher in US whites than blacks; however, there have been no large population-based studies comparing coronary calcification among US ethnic groups. Methods and Results - Using computed tomography, we measured coronary calcification in 6814 white, black, Hispanic, and Chinese men and women aged 45 to 84 years with no clinical cardiovascular disease who participated in the Multi-Ethnic Study of Atherosclerosis (MESA). The prevalence of coronary calcification (Agatston score >0) in these 4 ethnic groups was 70.4%, 52.1%, 56.5%, and 59.2%, respectively, in men (P<0.001) and 44.6%, 36.5%, 34.9%, and 41.9%, respectively, (P<0.001) in women. After adjustment for age, education, lipids, body mass index, smoking, diabetes, hypertension, treatment for hypercholesterolemia, gender, and scanning center, compared with whites, the relative risks for having coronary calcification were 0.78 (95% CI 0.74 to 0.82) in blacks, 0.85 (95% CI 0.79 to 0.91) in Hispanics, and 0.92 (95% CI 0.85 to 0.99) in Chinese. After similar adjustments, the amount of coronary calcification among those with an Agatston score >0 was greatest among whites, followed by Chinese (77% that of whites; 95% CI 62% to 96%), Hispanics (74%; 95% CI 61% to 90%), and blacks (69%; 95% CI 59% to 80%). Conclusions - We observed ethnic differences in the presence and quantity of coronary calcification that were not explained by coronary risk factors. Identification of the mechanism underlying these differences would further our understanding of the pathophysiology of coronary calcification and its clinical significance. Data on the predictive value of coronary calcium in different ethnic groups are needed.

Original languageEnglish (US)
Pages (from-to)1313-1320
Number of pages8
JournalCirculation
Volume111
Issue number10
DOIs
StatePublished - Mar 15 2005
Externally publishedYes

Fingerprint

Ethnic Groups
Atherosclerosis
Hispanic Americans
Coronary Artery Disease
Cardiovascular Diseases
Tomography
Calcium
Population
hydroquinone

Keywords

  • Atherosclerosis
  • Calcium
  • Coronary disease
  • Epidemiology

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Ethnic differences in coronary calcification : The Multi-Ethnic Study of Atherosclerosis (MESA). / Bild, Diane E.; Detrano, Robert; Peterson, Do; Guerci, Alan; Liu, Kiang; Shahar, Eyal; Ouyang, Pamela; Jackson, Sharon; Saad, Mohammed F.

In: Circulation, Vol. 111, No. 10, 15.03.2005, p. 1313-1320.

Research output: Contribution to journalArticle

Bild, DE, Detrano, R, Peterson, D, Guerci, A, Liu, K, Shahar, E, Ouyang, P, Jackson, S & Saad, MF 2005, 'Ethnic differences in coronary calcification: The Multi-Ethnic Study of Atherosclerosis (MESA)', Circulation, vol. 111, no. 10, pp. 1313-1320. https://doi.org/10.1161/01.CIR.0000157730.94423.4B
Bild, Diane E. ; Detrano, Robert ; Peterson, Do ; Guerci, Alan ; Liu, Kiang ; Shahar, Eyal ; Ouyang, Pamela ; Jackson, Sharon ; Saad, Mohammed F. / Ethnic differences in coronary calcification : The Multi-Ethnic Study of Atherosclerosis (MESA). In: Circulation. 2005 ; Vol. 111, No. 10. pp. 1313-1320.
@article{f32e44199755476b8d842d9b9daee220,
title = "Ethnic differences in coronary calcification: The Multi-Ethnic Study of Atherosclerosis (MESA)",
abstract = "Background - There is substantial evidence that coronary calcification, a marker for the presence and quantity of coronary atherosclerosis, is higher in US whites than blacks; however, there have been no large population-based studies comparing coronary calcification among US ethnic groups. Methods and Results - Using computed tomography, we measured coronary calcification in 6814 white, black, Hispanic, and Chinese men and women aged 45 to 84 years with no clinical cardiovascular disease who participated in the Multi-Ethnic Study of Atherosclerosis (MESA). The prevalence of coronary calcification (Agatston score >0) in these 4 ethnic groups was 70.4{\%}, 52.1{\%}, 56.5{\%}, and 59.2{\%}, respectively, in men (P<0.001) and 44.6{\%}, 36.5{\%}, 34.9{\%}, and 41.9{\%}, respectively, (P<0.001) in women. After adjustment for age, education, lipids, body mass index, smoking, diabetes, hypertension, treatment for hypercholesterolemia, gender, and scanning center, compared with whites, the relative risks for having coronary calcification were 0.78 (95{\%} CI 0.74 to 0.82) in blacks, 0.85 (95{\%} CI 0.79 to 0.91) in Hispanics, and 0.92 (95{\%} CI 0.85 to 0.99) in Chinese. After similar adjustments, the amount of coronary calcification among those with an Agatston score >0 was greatest among whites, followed by Chinese (77{\%} that of whites; 95{\%} CI 62{\%} to 96{\%}), Hispanics (74{\%}; 95{\%} CI 61{\%} to 90{\%}), and blacks (69{\%}; 95{\%} CI 59{\%} to 80{\%}). Conclusions - We observed ethnic differences in the presence and quantity of coronary calcification that were not explained by coronary risk factors. Identification of the mechanism underlying these differences would further our understanding of the pathophysiology of coronary calcification and its clinical significance. Data on the predictive value of coronary calcium in different ethnic groups are needed.",
keywords = "Atherosclerosis, Calcium, Coronary disease, Epidemiology",
author = "Bild, {Diane E.} and Robert Detrano and Do Peterson and Alan Guerci and Kiang Liu and Eyal Shahar and Pamela Ouyang and Sharon Jackson and Saad, {Mohammed F.}",
year = "2005",
month = "3",
day = "15",
doi = "10.1161/01.CIR.0000157730.94423.4B",
language = "English (US)",
volume = "111",
pages = "1313--1320",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Ethnic differences in coronary calcification

T2 - The Multi-Ethnic Study of Atherosclerosis (MESA)

AU - Bild, Diane E.

AU - Detrano, Robert

AU - Peterson, Do

AU - Guerci, Alan

AU - Liu, Kiang

AU - Shahar, Eyal

AU - Ouyang, Pamela

AU - Jackson, Sharon

AU - Saad, Mohammed F.

PY - 2005/3/15

Y1 - 2005/3/15

N2 - Background - There is substantial evidence that coronary calcification, a marker for the presence and quantity of coronary atherosclerosis, is higher in US whites than blacks; however, there have been no large population-based studies comparing coronary calcification among US ethnic groups. Methods and Results - Using computed tomography, we measured coronary calcification in 6814 white, black, Hispanic, and Chinese men and women aged 45 to 84 years with no clinical cardiovascular disease who participated in the Multi-Ethnic Study of Atherosclerosis (MESA). The prevalence of coronary calcification (Agatston score >0) in these 4 ethnic groups was 70.4%, 52.1%, 56.5%, and 59.2%, respectively, in men (P<0.001) and 44.6%, 36.5%, 34.9%, and 41.9%, respectively, (P<0.001) in women. After adjustment for age, education, lipids, body mass index, smoking, diabetes, hypertension, treatment for hypercholesterolemia, gender, and scanning center, compared with whites, the relative risks for having coronary calcification were 0.78 (95% CI 0.74 to 0.82) in blacks, 0.85 (95% CI 0.79 to 0.91) in Hispanics, and 0.92 (95% CI 0.85 to 0.99) in Chinese. After similar adjustments, the amount of coronary calcification among those with an Agatston score >0 was greatest among whites, followed by Chinese (77% that of whites; 95% CI 62% to 96%), Hispanics (74%; 95% CI 61% to 90%), and blacks (69%; 95% CI 59% to 80%). Conclusions - We observed ethnic differences in the presence and quantity of coronary calcification that were not explained by coronary risk factors. Identification of the mechanism underlying these differences would further our understanding of the pathophysiology of coronary calcification and its clinical significance. Data on the predictive value of coronary calcium in different ethnic groups are needed.

AB - Background - There is substantial evidence that coronary calcification, a marker for the presence and quantity of coronary atherosclerosis, is higher in US whites than blacks; however, there have been no large population-based studies comparing coronary calcification among US ethnic groups. Methods and Results - Using computed tomography, we measured coronary calcification in 6814 white, black, Hispanic, and Chinese men and women aged 45 to 84 years with no clinical cardiovascular disease who participated in the Multi-Ethnic Study of Atherosclerosis (MESA). The prevalence of coronary calcification (Agatston score >0) in these 4 ethnic groups was 70.4%, 52.1%, 56.5%, and 59.2%, respectively, in men (P<0.001) and 44.6%, 36.5%, 34.9%, and 41.9%, respectively, (P<0.001) in women. After adjustment for age, education, lipids, body mass index, smoking, diabetes, hypertension, treatment for hypercholesterolemia, gender, and scanning center, compared with whites, the relative risks for having coronary calcification were 0.78 (95% CI 0.74 to 0.82) in blacks, 0.85 (95% CI 0.79 to 0.91) in Hispanics, and 0.92 (95% CI 0.85 to 0.99) in Chinese. After similar adjustments, the amount of coronary calcification among those with an Agatston score >0 was greatest among whites, followed by Chinese (77% that of whites; 95% CI 62% to 96%), Hispanics (74%; 95% CI 61% to 90%), and blacks (69%; 95% CI 59% to 80%). Conclusions - We observed ethnic differences in the presence and quantity of coronary calcification that were not explained by coronary risk factors. Identification of the mechanism underlying these differences would further our understanding of the pathophysiology of coronary calcification and its clinical significance. Data on the predictive value of coronary calcium in different ethnic groups are needed.

KW - Atherosclerosis

KW - Calcium

KW - Coronary disease

KW - Epidemiology

UR - http://www.scopus.com/inward/record.url?scp=15244348756&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15244348756&partnerID=8YFLogxK

U2 - 10.1161/01.CIR.0000157730.94423.4B

DO - 10.1161/01.CIR.0000157730.94423.4B

M3 - Article

C2 - 15769774

AN - SCOPUS:15244348756

VL - 111

SP - 1313

EP - 1320

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 10

ER -