Eukaryotic Stress Granules: The Ins and Outs of Translation

J. Ross Buchan, Roy Parker

Research output: Contribution to journalReview articlepeer-review

785 Scopus citations

Abstract

The stress response in eukaryotic cells often inhibits translation initiation and leads to the formation of cytoplasmic RNA-protein complexes referred to as stress granules. Stress granules contain nontranslating mRNAs, translation initiation components, and many additional proteins affecting mRNA function. Stress granules have been proposed to affect mRNA translation and stability and have been linked to apoptosis and nuclear processes. Stress granules also interact with P-bodies, another cytoplasmic RNP granule containing nontranslating mRNA, translation repressors, and some mRNA degradation machinery. Together, stress granules and P-bodies reveal a dynamic cycle of distinct biochemical and compartmentalized mRNPs in the cytosol, with implications for the control of mRNA function.

Original languageEnglish (US)
Pages (from-to)932-941
Number of pages10
JournalMolecular cell
Volume36
Issue number6
DOIs
StatePublished - Dec 24 2009

Keywords

  • RNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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