Evaluation of a hydrogen laser vacuum ultraviolet source for photoionization mass spectrometry of pharmaceuticals

Jeffrey W. Finch, Kevin A. Toerne, Karl H. Schram, M Bonner Denton

Research output: Contribution to journalArticle

12 Scopus citations


A photoionization hydrogen laser time-of-flight mass spectrometer system (H2-TOFMS) has been evaluated for the rapid analysis of drugs of abuse and pharmaceutical agents extracted from prescription tablets and spiked urine samples. The spectra obtained using the H2-TOFMS showed primarily intact molecular ions (M+) after introduction by a heated probe and irradiation with vacuum ultraviolet (VUV) photons from the laser. Samples analyzed by this technique required only a simple solid-phase extraction step; no chromatographic separation or derivatization was necessary to identify the drugs of abuse or pharmaceutical agents.

Original languageEnglish (US)
Pages (from-to)15-22
Number of pages8
JournalRapid Communications in Mass Spectrometry
Issue number1
Publication statusPublished - 2005


ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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