Evaluation of amonafide in cervical cancer, phase II. A SWOG study

V. K. Malviya, P. Y. Liu, D. S. Alberts, E. A. Surwit, J. B. Craig, E. V. Hannigan

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

The Southwest Oncology Group conducted a Phase II study of amonafide in patients with metastatic or recurrent squamous cell cervical cancer. Twelve of the 15 patients were fully evaluable for response and toxicity. There were no clinical responses seen; 2 patients had stable disease while 13 had progressive disease. The major complication of this therapy was myelosuppression. Four patients had life-threatening granulocytopenia (<500/μl), 3 patients had life-threatening leukopenia (<1000/μl), while 2 patients had life-threatening thrombocytopenia (<25,000/μl). Amonafide has significant toxicity but appears to be an inactive drug in metastatic or recurrent squamous cell cancer of the cervix.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume15
Issue number1
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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