Evaluation of gentamicin therapy in newborns at a community hospital and development of simple dosing guidelines

John E. Murphy, Jean T. Carter

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

This study evaluated dosing and pharmacokinetics of gentamicin in neonates at a 600-bed community hospital. Pharmacokinetic data were used to predict steady-state gentamicin drug concentration measurements (DCMs) that the original and five simple alternative dosing regimens (2.5 mg/kg q16h, 2.5 mg/kg q18h, 3 mg/kg q24h, 3.5 mg/kg q24h, and 4 mg/kg q24h) would produce. Fifty infants with DCMs were divided into three groups based on gestational age and two weight groups to examine differences in pharmacokinetics, Gentamicin t1/2 was 8.1 (± 3.4) hours, V was 0.54 (± 0.20) L/kg, k was 0.10 (± 0.04) hours-1, and CL was 0.05 (± 0.02) L/h/kg. The percent (n = 50) of infants with DCMs in a therapeutic range-defined as peak concentrations of 4 to 8 mg/L and trough concentrations less than 2 mg/L-were 46%, 59%, 74%, 78%, 64%, and 32% for the original 2.5 mg/kg q16h, 2.5 mg/kg q18h, 3 mg/kg q24h, 3.5 mg/kg q24h, and 4 mg/kg q24h dosing methods, respectively.

Original languageEnglish (US)
Pages (from-to)1283-1289
Number of pages7
JournalHospital Pharmacy
Volume31
Issue number10
StatePublished - Oct 1 1996

Keywords

  • aminoglycosides
  • drug concentration measurement
  • gentamicin

ASJC Scopus subject areas

  • Pharmacy
  • Pharmacology
  • Pharmacology (medical)

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