Evaluation of hepatic injury arising during fluconazole therapy

M. A. Trujillo, J. N. Galgiani, R. E. Sampliner

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Previous reports have described hepatotoxicity associated with ketoconazole therapy. There is also concern that therapy with fluconazole might cause the same side effect as ketoconazole. We describe two patients who developed unexplained liver test abnormalities after beginning fluconazole therapy. To determine whether fluconazole might have been responsible, liver biopsies were performed. Specimens from both patients demonstrated an absence of hepatocyte necrosis, which, if present, would have necessitated discontinuation of fluconazole therapy. A critical review of other case reports of fluconazole-associated hepatitis also failed to produce a consistent picture. Our experience indicates that a liver biopsy may be useful in selected patients to exclude clinically relevant hepatotoxicity due to fluconazole therapy and to allow its continued use.

Original languageEnglish (US)
Pages (from-to)102-104
Number of pages3
JournalArchives of internal medicine
Volume154
Issue number1
DOIs
StatePublished - Jan 10 1994

ASJC Scopus subject areas

  • Internal Medicine

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