Evaluation of intravenous flavopiridol formulations

Ping Li, Hemali Patel, S. Esmail Tabibi, Rao Vishnuvajjala, Samuel H. Yalkowsky

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Flavopiridol is currently under consideration as a parenteral treatment of breast tumors. The solubility of this poorly water-soluble compound can be increased by a number of methods. However, because of its low water solubility, precipitation of the solubilized drug upon injection can be a problem. The potential of several flavopiridol formulations to precipitate is evaluated using a static serial dilution technique. It is shown that formulations containing up to 10 mg/mL of flavopiridol which produce negligible precipitation on dilution can be developed.

Original languageEnglish (US)
Pages (from-to)137-140
Number of pages4
JournalPDA Journal of Pharmaceutical Science and Technology
Volume53
Issue number3
StatePublished - May 1 1999

ASJC Scopus subject areas

  • Pharmaceutical Science

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