Flavopiridol is currently under consideration as a parenteral treatment of breast tumors. The solubility of this poorly water-soluble compound can be increased by a number of methods. However, because of its low water solubility, precipitation of the solubilized drug upon injection can be a problem. The potential of several flavopiridol formulations to precipitate is evaluated using a static serial dilution technique. It is shown that formulations containing up to 10 mg/mL of flavopiridol which produce negligible precipitation on dilution can be developed.
|Original language||English (US)|
|Number of pages||4|
|Journal||PDA Journal of Pharmaceutical Science and Technology|
|State||Published - May 1 1999|
ASJC Scopus subject areas
- Pharmaceutical Science