Evaluation of intravenous flavopiridol formulations

Ping Li, Hemali Patel, S. Esmail Tabibi, Rao Vishnuvajjala, Samuel H Yalkowsky

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Flavopiridol is currently under consideration as a parenteral treatment of breast tumors. The solubility of this poorly water-soluble compound can be increased by a number of methods. However, because of its low water solubility, precipitation of the solubilized drug upon injection can be a problem. The potential of several flavopiridol formulations to precipitate is evaluated using a static serial dilution technique. It is shown that formulations containing up to 10 mg/mL of flavopiridol which produce negligible precipitation on dilution can be developed.

Original languageEnglish (US)
Pages (from-to)137-140
Number of pages4
JournalPDA Journal of Pharmaceutical Science and Technology
Volume53
Issue number3
StatePublished - May 1999

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alvocidib
Solubility
Indicator Dilution Techniques
Water
Breast Neoplasms
Injections
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Evaluation of intravenous flavopiridol formulations. / Li, Ping; Patel, Hemali; Tabibi, S. Esmail; Vishnuvajjala, Rao; Yalkowsky, Samuel H.

In: PDA Journal of Pharmaceutical Science and Technology, Vol. 53, No. 3, 05.1999, p. 137-140.

Research output: Contribution to journalArticle

Li, P, Patel, H, Tabibi, SE, Vishnuvajjala, R & Yalkowsky, SH 1999, 'Evaluation of intravenous flavopiridol formulations', PDA Journal of Pharmaceutical Science and Technology, vol. 53, no. 3, pp. 137-140.
Li, Ping ; Patel, Hemali ; Tabibi, S. Esmail ; Vishnuvajjala, Rao ; Yalkowsky, Samuel H. / Evaluation of intravenous flavopiridol formulations. In: PDA Journal of Pharmaceutical Science and Technology. 1999 ; Vol. 53, No. 3. pp. 137-140.
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