Evaluation of syncardia total artificial heart using device thrombogenicity emulator

Yared Alemu, Gaurav Girdhar, Michalis Xenos, Thomas Claiborne, Jolyon Jesty, Shmuel Einav, Marvin J Slepian, Danny Bluestein

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The thrombogenicity of the left ventricle of the temporary Total Artificial Heart (TAH-t) (SynCardia Systems, Inc. Tucson, AZ) was evaluated using our device thrombogenicity emulator (DTE) methodology [1] that integrates advanced numerical modeling of the whole device combined with experimental measurements of platelet activity. The ejection phase of the cardiac cycle, including diaphragm motion, was modeled with fully-coupled fluid structure interaction (FSI) simulation. Stress loading histories of several thousand platelet trajectories were extracted from these simulations and collapsed into quantitative probability density function (PDF) distributions that represent the TAH-t thrombogenic footprint. Representative stress-loading waveforms with substantially higher stress accumulation (high propensity to cause platelet activation) were replicated in computer controlled hemodynamic shearing device (HSD), where the effect on platelet activation was measured with a modified prothrombinase assay. By determining the platelet stress accumulation distribution, the thrombogenic signature unique to specific TAH design from the results, this methodology facilitates virtual evaluation and optimization of various designs.

Original languageEnglish (US)
Title of host publicationASME 2011 Summer Bioengineering Conference, SBC 2011
Pages163-164
Number of pages2
EditionPARTS A AND B
DOIs
StatePublished - 2011
EventASME 2011 Summer Bioengineering Conference, SBC 2011 - Farmington, PA, United States
Duration: Jun 22 2011Jun 25 2011

Other

OtherASME 2011 Summer Bioengineering Conference, SBC 2011
CountryUnited States
CityFarmington, PA
Period6/22/116/25/11

Fingerprint

Artificial heart
Platelets
Chemical activation
Fluid structure interaction
Hemodynamics
Thromboplastin
Diaphragms
Shearing
Probability density function
Assays
Trajectories

ASJC Scopus subject areas

  • Bioengineering

Cite this

Alemu, Y., Girdhar, G., Xenos, M., Claiborne, T., Jesty, J., Einav, S., ... Bluestein, D. (2011). Evaluation of syncardia total artificial heart using device thrombogenicity emulator. In ASME 2011 Summer Bioengineering Conference, SBC 2011 (PARTS A AND B ed., pp. 163-164) https://doi.org/10.1115/SBC2011-53420

Evaluation of syncardia total artificial heart using device thrombogenicity emulator. / Alemu, Yared; Girdhar, Gaurav; Xenos, Michalis; Claiborne, Thomas; Jesty, Jolyon; Einav, Shmuel; Slepian, Marvin J; Bluestein, Danny.

ASME 2011 Summer Bioengineering Conference, SBC 2011. PARTS A AND B. ed. 2011. p. 163-164.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Alemu, Y, Girdhar, G, Xenos, M, Claiborne, T, Jesty, J, Einav, S, Slepian, MJ & Bluestein, D 2011, Evaluation of syncardia total artificial heart using device thrombogenicity emulator. in ASME 2011 Summer Bioengineering Conference, SBC 2011. PARTS A AND B edn, pp. 163-164, ASME 2011 Summer Bioengineering Conference, SBC 2011, Farmington, PA, United States, 6/22/11. https://doi.org/10.1115/SBC2011-53420
Alemu Y, Girdhar G, Xenos M, Claiborne T, Jesty J, Einav S et al. Evaluation of syncardia total artificial heart using device thrombogenicity emulator. In ASME 2011 Summer Bioengineering Conference, SBC 2011. PARTS A AND B ed. 2011. p. 163-164 https://doi.org/10.1115/SBC2011-53420
Alemu, Yared ; Girdhar, Gaurav ; Xenos, Michalis ; Claiborne, Thomas ; Jesty, Jolyon ; Einav, Shmuel ; Slepian, Marvin J ; Bluestein, Danny. / Evaluation of syncardia total artificial heart using device thrombogenicity emulator. ASME 2011 Summer Bioengineering Conference, SBC 2011. PARTS A AND B. ed. 2011. pp. 163-164
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