Evaluation of the biodistribution of serinolamide-derivatized c60 fullerene

Nicholas G. Zaibaq, Alyssa C. Pollard, Michael J. Collins, Federica Pisaneschi, Mark D. Pagel, Lon J. Wilson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Carbon nanoparticles have consistently been of great interest in medicine. However, there are currently no clinical materials based on carbon nanoparticles, due to inconsistent biodistribution and excretion data. In this work, we have synthesized a novel C60 derivative with a metal chelating agent (NOTA) covalently bound to the C60 cage and radiolabeled with copper-64 (t1/2 = 12.7 h). Biodistribution of the material was assessed in vivo using positron emission tomography (PET). Bingel-Hirsch chemistry was employed to functionalize the fullerene cage with highly water-soluble serinolamide groups allowing this new C60 conjugate to clear quickly from mice almost exclusively through the kidneys. Comparing the present results to the larger context of reports of biocompatible fullerene derivatives, this work offers an important evaluation of the in vivo biodistribution, using experimental evidence to establish functionalization guidelines for future C60-based biomedical platforms.

Original languageEnglish (US)
Article number143
JournalNanomaterials
Volume10
Issue number1
DOIs
StatePublished - Jan 2020
Externally publishedYes

Keywords

  • Biodistribution
  • Fullerene
  • PET
  • Pharmacokinetics
  • Serinolamide

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Science(all)

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