Evaluation of topically applied trans-retinoic acid in the treatment of cervical intraepithelial lesions

Earl A. Surwit, Vivian Graham, William Droegemueller, David Alberts, Milos Chvapil, Robert T. Dorr, John R. Davis, Frank L. Meyskens

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

The prevention and/or suppression of preneoplastic foci in animals has boen convincingly demonstrated with the use of a variety of compounds, including retinoids. We report here a phase I II trial of β-trans-retinoic acid delivered via a collegen sponge/diaphragm insert for neoplasia of the cervix. Eighteen patients with biopsy-proved grades 2 and 3 cervical intraepithelial neoplasia underwent four consecutive daily applications of trans-retinoic acid to the cervix. Conization of the cervix was performed 4 weeks later. Significant vaginal toxicity in 10 of 18 (55%) patients was unrelated to the concentration or carrying media of the drug. A reduction in size of the intraepithelial lesion was noted by colposcopy in six of 18 (33%) patients with complete resolution of disease at conization in two patients. A new delivery system designed to avoid vaginal toxicity while defining the optimal concentration and dosing schedule for these patients is currently under investigation.

Original languageEnglish (US)
Pages (from-to)821-823
Number of pages3
JournalAmerican journal of obstetrics and gynecology
Volume143
Issue number7
DOIs
StatePublished - Aug 1 1982

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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