Evaluation of topically applied trans-retinoic acid in the treatment of cervical intraepithelial lesions

Earl A. Surwit, Vivian Graham, William Droegemueller, David S Alberts, Milos Chvapil, Robert T Dorr, John R. Davis, Frank L. Meyskens

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The prevention and/or suppression of preneoplastic foci in animals has boen convincingly demonstrated with the use of a variety of compounds, including retinoids. We report here a phase I II trial of β-trans-retinoic acid delivered via a collegen sponge/diaphragm insert for neoplasia of the cervix. Eighteen patients with biopsy-proved grades 2 and 3 cervical intraepithelial neoplasia underwent four consecutive daily applications of trans-retinoic acid to the cervix. Conization of the cervix was performed 4 weeks later. Significant vaginal toxicity in 10 of 18 (55%) patients was unrelated to the concentration or carrying media of the drug. A reduction in size of the intraepithelial lesion was noted by colposcopy in six of 18 (33%) patients with complete resolution of disease at conization in two patients. A new delivery system designed to avoid vaginal toxicity while defining the optimal concentration and dosing schedule for these patients is currently under investigation.

Original languageEnglish (US)
Pages (from-to)821-823
Number of pages3
JournalAmerican Journal of Obstetrics and Gynecology
Volume143
Issue number7
StatePublished - Aug 1 1982

Fingerprint

Tretinoin
Cervix Uteri
Conization
Colposcopy
Cervical Intraepithelial Neoplasia
Retinoids
Porifera
Therapeutics
Diaphragm
Appointments and Schedules
Biopsy
Pharmaceutical Preparations
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Evaluation of topically applied trans-retinoic acid in the treatment of cervical intraepithelial lesions. / Surwit, Earl A.; Graham, Vivian; Droegemueller, William; Alberts, David S; Chvapil, Milos; Dorr, Robert T; Davis, John R.; Meyskens, Frank L.

In: American Journal of Obstetrics and Gynecology, Vol. 143, No. 7, 01.08.1982, p. 821-823.

Research output: Contribution to journalArticle

Surwit, EA, Graham, V, Droegemueller, W, Alberts, DS, Chvapil, M, Dorr, RT, Davis, JR & Meyskens, FL 1982, 'Evaluation of topically applied trans-retinoic acid in the treatment of cervical intraepithelial lesions', American Journal of Obstetrics and Gynecology, vol. 143, no. 7, pp. 821-823.
Surwit, Earl A. ; Graham, Vivian ; Droegemueller, William ; Alberts, David S ; Chvapil, Milos ; Dorr, Robert T ; Davis, John R. ; Meyskens, Frank L. / Evaluation of topically applied trans-retinoic acid in the treatment of cervical intraepithelial lesions. In: American Journal of Obstetrics and Gynecology. 1982 ; Vol. 143, No. 7. pp. 821-823.
@article{ef73f9714b614939b6dc754dc3e6be2b,
title = "Evaluation of topically applied trans-retinoic acid in the treatment of cervical intraepithelial lesions",
abstract = "The prevention and/or suppression of preneoplastic foci in animals has boen convincingly demonstrated with the use of a variety of compounds, including retinoids. We report here a phase I II trial of β-trans-retinoic acid delivered via a collegen sponge/diaphragm insert for neoplasia of the cervix. Eighteen patients with biopsy-proved grades 2 and 3 cervical intraepithelial neoplasia underwent four consecutive daily applications of trans-retinoic acid to the cervix. Conization of the cervix was performed 4 weeks later. Significant vaginal toxicity in 10 of 18 (55{\%}) patients was unrelated to the concentration or carrying media of the drug. A reduction in size of the intraepithelial lesion was noted by colposcopy in six of 18 (33{\%}) patients with complete resolution of disease at conization in two patients. A new delivery system designed to avoid vaginal toxicity while defining the optimal concentration and dosing schedule for these patients is currently under investigation.",
author = "Surwit, {Earl A.} and Vivian Graham and William Droegemueller and Alberts, {David S} and Milos Chvapil and Dorr, {Robert T} and Davis, {John R.} and Meyskens, {Frank L.}",
year = "1982",
month = "8",
day = "1",
language = "English (US)",
volume = "143",
pages = "821--823",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "7",

}

TY - JOUR

T1 - Evaluation of topically applied trans-retinoic acid in the treatment of cervical intraepithelial lesions

AU - Surwit, Earl A.

AU - Graham, Vivian

AU - Droegemueller, William

AU - Alberts, David S

AU - Chvapil, Milos

AU - Dorr, Robert T

AU - Davis, John R.

AU - Meyskens, Frank L.

PY - 1982/8/1

Y1 - 1982/8/1

N2 - The prevention and/or suppression of preneoplastic foci in animals has boen convincingly demonstrated with the use of a variety of compounds, including retinoids. We report here a phase I II trial of β-trans-retinoic acid delivered via a collegen sponge/diaphragm insert for neoplasia of the cervix. Eighteen patients with biopsy-proved grades 2 and 3 cervical intraepithelial neoplasia underwent four consecutive daily applications of trans-retinoic acid to the cervix. Conization of the cervix was performed 4 weeks later. Significant vaginal toxicity in 10 of 18 (55%) patients was unrelated to the concentration or carrying media of the drug. A reduction in size of the intraepithelial lesion was noted by colposcopy in six of 18 (33%) patients with complete resolution of disease at conization in two patients. A new delivery system designed to avoid vaginal toxicity while defining the optimal concentration and dosing schedule for these patients is currently under investigation.

AB - The prevention and/or suppression of preneoplastic foci in animals has boen convincingly demonstrated with the use of a variety of compounds, including retinoids. We report here a phase I II trial of β-trans-retinoic acid delivered via a collegen sponge/diaphragm insert for neoplasia of the cervix. Eighteen patients with biopsy-proved grades 2 and 3 cervical intraepithelial neoplasia underwent four consecutive daily applications of trans-retinoic acid to the cervix. Conization of the cervix was performed 4 weeks later. Significant vaginal toxicity in 10 of 18 (55%) patients was unrelated to the concentration or carrying media of the drug. A reduction in size of the intraepithelial lesion was noted by colposcopy in six of 18 (33%) patients with complete resolution of disease at conization in two patients. A new delivery system designed to avoid vaginal toxicity while defining the optimal concentration and dosing schedule for these patients is currently under investigation.

UR - http://www.scopus.com/inward/record.url?scp=0019983966&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019983966&partnerID=8YFLogxK

M3 - Article

C2 - 7048932

AN - SCOPUS:0019983966

VL - 143

SP - 821

EP - 823

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 7

ER -