Evaluation of vaccination with a commercial subunit vaccine on shedding of Salmonella enterica in subclinically infected dairy cows

Luke C. Heider, Richard W. Meiring, Armando E. Hoet, Wondwossen A. Gebreyes, Julie A. Funk, Thomas E. Wittum

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Objective - To estimate the efficacy of a commercially available Salmonella enterica subunit vaccine on the subclinical shedding of S enterica in dairy cattle. Design - Randomized, controlled trial. Animals - 175 mature cows on 2 dairy farms with a history of S enterica infection. Procedures - 25% of the mature cows from each herd were systematically randomized to receive an S enterica subunit vaccine following label guidelines. The remaining 75% of cows in each herd served as nonvaccinated controls. Fecal samples were collected from all cows at the time of initial vaccination (day O), booster vaccination (day 14), 2 weeks following the booster vaccination (day 28), and 10 weeks following the start of the trial (day 70). All samples were processed on the day of collection and cultured for S enterica. Results - 651 fecal samples were obtained over the entire study period. Salmonella enterica was recovered from 46 (7.1 %) of the samples. Shedding of S enterica was similar for vaccinated and nonvaccinated control cows on each of the collection dates. Conclusions and Clinical Relevance - The study revealed no evidence that extralabel vaccination with a commercial subunit S enterica vaccine reduced shedding of S enterica in subclinically infected dairy cows in these herds.

Original languageEnglish (US)
Pages (from-to)466-469
Number of pages4
JournalJournal of the American Veterinary Medical Association
Volume233
Issue number3
DOIs
StatePublished - Aug 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)

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