Evidence for cholecystokinin-like immunoreactive neurons in the rat medulla oblongata which project to the spinal cord

Patrick W Mantyh, S. P. Hunt

Research output: Contribution to journalArticle

95 Scopus citations


The distribution of cholecystokinin-like immunoreactive (CCK-LI) neurons has been mapped in the rat medulla after local and intracerebroventricular colchicine injections. CCK-positive neurons were found in the nucleus raphe magnus, nucleus raphe pallidus, nucleus raphe obscurus, nucleus paragigantocellularis pars α, and a population of ventral medullary neurons. Combined retrograde tracing with the fluorescent dye True Blue and indirect immunofluorescence for visualizing CCK neurons suggested that there was a CCK-LI system originating in the medulla and projecting to the spinal cord. Additional double labelling experiments established that some of these CCK-LI containing neurons also contain 5-HT.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalBrain Research
Issue number1
Publication statusPublished - Jan 16 1984
Externally publishedYes



  • 5-HT
  • cholecystokinin
  • coexistence
  • medulla
  • raphe
  • spinal cord
  • True Blue

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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