Evidence for Reduced Autobiographical Memory Episodic Specificity in Cognitively Normal Middle-Aged and Older Individuals at Increased Risk for Alzheimer's Disease Dementia

Matthew D. Grilli, Aubrey A. Wank, John J. Bercel, Lee Ryan

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Objectives: Alzheimer's disease (AD) typically eludes clinical detection for years, if not decades. The identification of subtle cognitive decline associated with preclinical AD would not only advance understanding of the disease, but also provide clinical targets to assess preventative and early intervention treatments. Disrupted retrieval of detailed episodic autobiographical memories may be a sensitive indicator of subtle cognitive decline, because this type of memory taxes a core neural network affected by preclinical AD neuropathology. Methods: To begin to address this idea, we assessed the episodic specificity of autobiographical memories retrieved by cognitively normal middle-aged and older individuals who are carriers of the apolipoprotein E ϵ4 allele - a population at increased risk for subtle cognitive decline related to neuropathological risk factors for AD. We compared the ϵ4 carriers to non-carriers of ϵ4 similar in age, education, and gender. Results: The ϵ4 carriers did not perform worse than the non-carriers on a comprehensive battery of neuropsychological tests. In contrast, as a group, the ϵ4 carriers generated autobiographical memories that were reduced in internal or episodic details relative to non-carriers. Conclusions: These findings support the notion that reduced autobiographical episodic detail generation may be a marker of subtle cognitive decline associated with AD. (JINS, 2018, 24, 1073-1183)

Original languageEnglish (US)
Pages (from-to)1073-1083
Number of pages11
JournalJournal of the International Neuropsychological Society
Volume24
Issue number10
DOIs
StatePublished - Nov 1 2018

Keywords

  • APOE
  • Aging
  • Alzheimer's disease
  • Autobiographical memory
  • Episodic memory
  • Preclinical

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

Fingerprint

Dive into the research topics of 'Evidence for Reduced Autobiographical Memory Episodic Specificity in Cognitively Normal Middle-Aged and Older Individuals at Increased Risk for Alzheimer's Disease Dementia'. Together they form a unique fingerprint.

Cite this