Abstract
To investigate the possibility that serotonin plays a role in the sexually dimorphic development of a nucleus in the medial preoptic area of the rat brain, p-chlorophenylalanine, an inhibitor of serotonin biosynthesis, was administered to pregnant dams from day 8 of gestation until parturition. This treatment did not alter plasma steroid levels but increased the volume of the sexually dimorphic nucleus in female neonates to that of control males. Thus, serotonin is implicated as a neurochemical which may be involved in the sexually dimorphic development of the preoptic area.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 278-282 |
| Number of pages | 5 |
| Journal | Developmental Brain Research |
| Volume | 30 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1986 |
| Externally published | Yes |
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Keywords
- Development
- Preoptic area
- Serotonin (5-HT)
- Sexual dimorphism
- Steroid
ASJC Scopus subject areas
- Developmental Biology
- Developmental Neuroscience
Cite this
Evidence that serotonin is involved in the sexually dimorphic development of the preoptic area in the rat brain. / Handa, Robert J; Hines, Melissa; Schoonmaker, Judith N.; Shryne, James E.; Gorski, Roger A.
In: Developmental Brain Research, Vol. 30, No. 2, 1986, p. 278-282.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evidence that serotonin is involved in the sexually dimorphic development of the preoptic area in the rat brain
AU - Handa, Robert J
AU - Hines, Melissa
AU - Schoonmaker, Judith N.
AU - Shryne, James E.
AU - Gorski, Roger A.
PY - 1986
Y1 - 1986
N2 - To investigate the possibility that serotonin plays a role in the sexually dimorphic development of a nucleus in the medial preoptic area of the rat brain, p-chlorophenylalanine, an inhibitor of serotonin biosynthesis, was administered to pregnant dams from day 8 of gestation until parturition. This treatment did not alter plasma steroid levels but increased the volume of the sexually dimorphic nucleus in female neonates to that of control males. Thus, serotonin is implicated as a neurochemical which may be involved in the sexually dimorphic development of the preoptic area.
AB - To investigate the possibility that serotonin plays a role in the sexually dimorphic development of a nucleus in the medial preoptic area of the rat brain, p-chlorophenylalanine, an inhibitor of serotonin biosynthesis, was administered to pregnant dams from day 8 of gestation until parturition. This treatment did not alter plasma steroid levels but increased the volume of the sexually dimorphic nucleus in female neonates to that of control males. Thus, serotonin is implicated as a neurochemical which may be involved in the sexually dimorphic development of the preoptic area.
KW - Development
KW - Preoptic area
KW - Serotonin (5-HT)
KW - Sexual dimorphism
KW - Steroid
UR - http://www.scopus.com/inward/record.url?scp=0023007284&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023007284&partnerID=8YFLogxK
U2 - 10.1016/0165-3806(86)90120-3
DO - 10.1016/0165-3806(86)90120-3
M3 - Article
VL - 30
SP - 278
EP - 282
JO - Developmental Brain Research
JF - Developmental Brain Research
SN - 0165-3806
IS - 2
ER -