Evidence that serotonin is involved in the sexually dimorphic development of the preoptic area in the rat brain

Robert J Handa, Melissa Hines, Judith N. Schoonmaker, James E. Shryne, Roger A. Gorski

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

To investigate the possibility that serotonin plays a role in the sexually dimorphic development of a nucleus in the medial preoptic area of the rat brain, p-chlorophenylalanine, an inhibitor of serotonin biosynthesis, was administered to pregnant dams from day 8 of gestation until parturition. This treatment did not alter plasma steroid levels but increased the volume of the sexually dimorphic nucleus in female neonates to that of control males. Thus, serotonin is implicated as a neurochemical which may be involved in the sexually dimorphic development of the preoptic area.

Original languageEnglish (US)
Pages (from-to)278-282
Number of pages5
JournalDevelopmental Brain Research
Volume30
Issue number2
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Preoptic Area
Serotonin
Brain
Fenclonine
Steroids
Parturition
Pregnancy

Keywords

  • Development
  • Preoptic area
  • Serotonin (5-HT)
  • Sexual dimorphism
  • Steroid

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Evidence that serotonin is involved in the sexually dimorphic development of the preoptic area in the rat brain. / Handa, Robert J; Hines, Melissa; Schoonmaker, Judith N.; Shryne, James E.; Gorski, Roger A.

In: Developmental Brain Research, Vol. 30, No. 2, 1986, p. 278-282.

Research output: Contribution to journalArticle

Handa, Robert J ; Hines, Melissa ; Schoonmaker, Judith N. ; Shryne, James E. ; Gorski, Roger A. / Evidence that serotonin is involved in the sexually dimorphic development of the preoptic area in the rat brain. In: Developmental Brain Research. 1986 ; Vol. 30, No. 2. pp. 278-282.
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