Evolution of CST function in telomere maintenance

Carolyn M. Price, Kara A. Boltz, Mary F. Chaiken, Jason A. Stewart, Mark A. Beilstein, Dorothy E. Shippen

Research output: Contribution to journalReview articlepeer-review

112 Scopus citations

Abstract

Telomeres consist of an elaborate, higher-order DNA architecture, and a suite of proteins that provide protection for the chromosome terminus by blocking inappropriate recombination and nucleolytic attack. In addition, telomeres facilitate telomeric DNA replication by physical interactions with telomerase and the lagging strand replication machinery. The prevailing view has been that two distinct telomere capping complexes evolved, shelterin in vertebrates and a trimeric complex comprised of Cdc13, Stn1 and Ten1 (CST) in yeast. The recent discovery of a CST-like complex in plants and humans raises new questions about the composition of telomeres and their regulatory mechanisms in multicellular eukaryotes. In this review we discuss the evolving functions and interactions of CST components and their contributions to chromosome end protection and DNA replication.

Original languageEnglish (US)
Pages (from-to)3177-3185
Number of pages9
JournalCell Cycle
Volume9
Issue number16
DOIs
StatePublished - Aug 15 2010
Externally publishedYes

Keywords

  • Arabidopsis
  • CTC1
  • DNA polymerase alpha
  • OB-fold
  • RPA
  • STN1
  • TEN1
  • Telomerase
  • Telomere
  • Telomere protein

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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