Evolution of the Papillomaviridae

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

Viruses belonging to the Papillomaviridae family have been isolated from a variety of mammals, birds and non-avian reptiles. It is likely that most, if not all, amniotes carry a broad array of viral types. To date, the complete genomic sequence of more than 240 distinct viral types has been characterized at the nucleotide level. The analysis of this sequence information has begun to shed light on the evolutionary history of this important virus family. The available data suggests that many different evolutionary mechanisms have influenced the papillomavirus phylogenetic tree. Increasing evidence supports that the ancestral papillomavirus initially specialized to infect different ecological niches on the host. This episode of niche sorting was followed by extensive episodes of co-speciation with the host. This review attempts to summarize our current understanding of the papillomavirus evolution.

Original languageEnglish (US)
Pages (from-to)11-20
Number of pages10
JournalVirology
Volume445
Issue number1-2
DOIs
StatePublished - Oct 1 2013
Externally publishedYes

Keywords

  • Co-evolution
  • Codon usage
  • Evolution
  • Mutation rate
  • Niche adaptation
  • Papillomaviridae
  • Recombination

ASJC Scopus subject areas

  • Virology

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