Evolutionary relationships of wild hominids recapitulated by gut microbial communities

Howard Ochman, Michael Worobey, Chih Horng Kuo, Jean Bosco N. Ndjango, Martine Peeters, Beatrice H. Hahn, Philip Hugenholtz

Research output: Contribution to journalArticle

286 Scopus citations

Abstract

Multiple factors over the lifetime of an individual, including diet, geography, and physiologic state, will influence the microbial communities within the primate gut. To determine the source of variation in the composition of the microbiota within and among species, we investigated the distal gut microbial communities harbored by great apes, as present in fecal samples recovered within their native ranges. We found that the branching order of host-species phylogenies based on the composition of these microbial communities is completely congruent with the known relationships of the hosts. Although the gut is initially and continuously seeded by bacteria that are acquired from external sources, we establish that over evolutionary timescales, the composition of the gut microbiota among great ape species is phylogenetically conserved and has diverged in a manner consistent with vertical inheritance.

Original languageEnglish (US)
Article numbere1000546
JournalPLoS biology
Volume8
Issue number11
DOIs
StatePublished - Nov 1 2010

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

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    Ochman, H., Worobey, M., Kuo, C. H., Ndjango, J. B. N., Peeters, M., Hahn, B. H., & Hugenholtz, P. (2010). Evolutionary relationships of wild hominids recapitulated by gut microbial communities. PLoS biology, 8(11), [e1000546]. https://doi.org/10.1371/journal.pbio.1000546