Evolving paradigms in neuroimaging of the ischemic penumbra

Stella Kidwell, Jeffry R. Alger, Jeffrey L. Saver

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Identification of the ischemic penumbra in the acute stroke clinical setting is an important goal for stroke researchers and clinicians. Various models for imaging the penumbra with MRI have been proposed, including the pioneering diffusion-perfusion mismatch model and later multivariate approaches. A number of multicenter clinical trials are now under way to test these models and confirm the utility of MRI-based treatment decisions. Present knowledge about MRI visualization of the salvageable penumbra suggests a promising future in which MRI studies are performed routinely in the acute stroke setting and the data provided by these MRI studies assist in individualizing therapeutic decisions and identifying effective therapies that can be delivered at late time points.

Original languageEnglish (US)
Pages (from-to)2662-2665
Number of pages4
JournalStroke
Volume35
Issue number11 SUPPL. 1
DOIs
StatePublished - Nov 2004
Externally publishedYes

Fingerprint

Neuroimaging
Stroke
Multicenter Studies
Perfusion
Research Personnel
Clinical Trials
Therapeutics

Keywords

  • Acute care
  • Magnetic resonance imaging
  • Stroke, acute

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Evolving paradigms in neuroimaging of the ischemic penumbra. / Kidwell, Stella; Alger, Jeffry R.; Saver, Jeffrey L.

In: Stroke, Vol. 35, No. 11 SUPPL. 1, 11.2004, p. 2662-2665.

Research output: Contribution to journalArticle

Kidwell, Stella ; Alger, Jeffry R. ; Saver, Jeffrey L. / Evolving paradigms in neuroimaging of the ischemic penumbra. In: Stroke. 2004 ; Vol. 35, No. 11 SUPPL. 1. pp. 2662-2665.
@article{6ac51e6ca62c4b5c9e4b5180f17a42d9,
title = "Evolving paradigms in neuroimaging of the ischemic penumbra",
abstract = "Identification of the ischemic penumbra in the acute stroke clinical setting is an important goal for stroke researchers and clinicians. Various models for imaging the penumbra with MRI have been proposed, including the pioneering diffusion-perfusion mismatch model and later multivariate approaches. A number of multicenter clinical trials are now under way to test these models and confirm the utility of MRI-based treatment decisions. Present knowledge about MRI visualization of the salvageable penumbra suggests a promising future in which MRI studies are performed routinely in the acute stroke setting and the data provided by these MRI studies assist in individualizing therapeutic decisions and identifying effective therapies that can be delivered at late time points.",
keywords = "Acute care, Magnetic resonance imaging, Stroke, acute",
author = "Stella Kidwell and Alger, {Jeffry R.} and Saver, {Jeffrey L.}",
year = "2004",
month = "11",
doi = "10.1161/01.STR.0000143222.13069.70",
language = "English (US)",
volume = "35",
pages = "2662--2665",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "11 SUPPL. 1",

}

TY - JOUR

T1 - Evolving paradigms in neuroimaging of the ischemic penumbra

AU - Kidwell, Stella

AU - Alger, Jeffry R.

AU - Saver, Jeffrey L.

PY - 2004/11

Y1 - 2004/11

N2 - Identification of the ischemic penumbra in the acute stroke clinical setting is an important goal for stroke researchers and clinicians. Various models for imaging the penumbra with MRI have been proposed, including the pioneering diffusion-perfusion mismatch model and later multivariate approaches. A number of multicenter clinical trials are now under way to test these models and confirm the utility of MRI-based treatment decisions. Present knowledge about MRI visualization of the salvageable penumbra suggests a promising future in which MRI studies are performed routinely in the acute stroke setting and the data provided by these MRI studies assist in individualizing therapeutic decisions and identifying effective therapies that can be delivered at late time points.

AB - Identification of the ischemic penumbra in the acute stroke clinical setting is an important goal for stroke researchers and clinicians. Various models for imaging the penumbra with MRI have been proposed, including the pioneering diffusion-perfusion mismatch model and later multivariate approaches. A number of multicenter clinical trials are now under way to test these models and confirm the utility of MRI-based treatment decisions. Present knowledge about MRI visualization of the salvageable penumbra suggests a promising future in which MRI studies are performed routinely in the acute stroke setting and the data provided by these MRI studies assist in individualizing therapeutic decisions and identifying effective therapies that can be delivered at late time points.

KW - Acute care

KW - Magnetic resonance imaging

KW - Stroke, acute

UR - http://www.scopus.com/inward/record.url?scp=7644241715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7644241715&partnerID=8YFLogxK

U2 - 10.1161/01.STR.0000143222.13069.70

DO - 10.1161/01.STR.0000143222.13069.70

M3 - Article

C2 - 15472112

AN - SCOPUS:7644241715

VL - 35

SP - 2662

EP - 2665

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 11 SUPPL. 1

ER -