Examination of Lens calcium balance using 45ca uptake studies

Nicholas A. Delamere, Christopher A. Paterson

Research output: Contribution to journalArticle

Abstract

The utility of Ca efflux studies to examine lens calcium balance is limited because of the dominant contribution of efflux from the extracellular space of the lens. On the other hand, examination of lens "Ca uptake characteristics can generate valuable information regarding the mechanism by which calcium is largely restricted from the intracellular compartment. Such studies have enabled us to demonstrate that the access of calcium to the intracellular compartment is dependent to some extent upon the concentration of calcium in the extracellular environment. Additionally, experimental evidence speaks against extracellular binding of calcium. Finally, lens membrane permeability to calcium appears to be independent of membrane voltage.

Original languageEnglish (US)
Pages (from-to)447-452
Number of pages6
JournalCurrent Eye Research
Volume4
Issue number4
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

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ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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