Exchangeable zinc pool size in infants is related to key variables of zinc homeostasis

Nancy F. Krebs, K. Michael Hambidge, Jamie E. Westcott, Leland V. Miller, Lei Sian, Melanie L Bell, Gary Grunwald

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The exchangeable zinc pool (EZP) is the sum of the combined pools that exchange with zinc in the plasma within 48-72 h and is thought to be critical for zinc-dependent biological processes. The size of the EZP in adults has been found to be positively related to dietary zinc intake, daily absorbed zinc and fecal excretion of endogenous zinc. In this study, we examine data on EZP size in relation to variables of zinc homeostasis in normal infants on different feeding regimens. Data from 45 male infants who participated in one of four different studies contribute to the analysis. The feeding regimens include exclusive breastfeeding (n = 9; age, 2-5 mo); breastfeeding plus modest supplementation with cow's milk-based formula (n = 16; age, 3-4 mo); exclusive formula feeding (n = 4; age, 3-4 mo) and exclusive breastfeeding plus complementary foods (n = 16; age, 7 mo). Fractional absorption was determined by fecal monitoring after oral administration of zinc-stable isotopes. Urine enrichment 4-8 d posttracer was used to determine endogenous fecal zinc (7-mo-old infants excepted) and EZP size. Univariate correlations and multivariate regression analyses were performed between EZP and age, weight, dietary zinc intake, fractional absorption, total absorbed zinc and endogenous fecal zinc. Results include no significant relationship between EZP size and age, body weight or fractional absorption but a positive relationship with daily absorbed zinc and endogenous fecal zinc excretion. We conclude that the amount of absorbed zinc is not tightly regulated, and that endogenous fecal zinc is dependent on and responsive to the zinc status of the organism.

Original languageEnglish (US)
JournalJournal of Nutrition
Volume133
Issue number5 SUPPL. 2
StatePublished - May 1 2003
Externally publishedYes

Fingerprint

Zinc
homeostasis
Homeostasis
zinc
breast feeding
exchangeable zinc
Breast Feeding
excretion
Zinc Isotopes
bottle feeding
complementary foods
Biological Phenomena
oral administration
stable isotopes
urine

Keywords

  • Absorbed zinc
  • Exchangeable zinc pool
  • Fractional absorption
  • Zinc homeostasis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Krebs, N. F., Hambidge, K. M., Westcott, J. E., Miller, L. V., Sian, L., Bell, M. L., & Grunwald, G. (2003). Exchangeable zinc pool size in infants is related to key variables of zinc homeostasis. Journal of Nutrition, 133(5 SUPPL. 2).

Exchangeable zinc pool size in infants is related to key variables of zinc homeostasis. / Krebs, Nancy F.; Hambidge, K. Michael; Westcott, Jamie E.; Miller, Leland V.; Sian, Lei; Bell, Melanie L; Grunwald, Gary.

In: Journal of Nutrition, Vol. 133, No. 5 SUPPL. 2, 01.05.2003.

Research output: Contribution to journalArticle

Krebs, NF, Hambidge, KM, Westcott, JE, Miller, LV, Sian, L, Bell, ML & Grunwald, G 2003, 'Exchangeable zinc pool size in infants is related to key variables of zinc homeostasis', Journal of Nutrition, vol. 133, no. 5 SUPPL. 2.
Krebs NF, Hambidge KM, Westcott JE, Miller LV, Sian L, Bell ML et al. Exchangeable zinc pool size in infants is related to key variables of zinc homeostasis. Journal of Nutrition. 2003 May 1;133(5 SUPPL. 2).
Krebs, Nancy F. ; Hambidge, K. Michael ; Westcott, Jamie E. ; Miller, Leland V. ; Sian, Lei ; Bell, Melanie L ; Grunwald, Gary. / Exchangeable zinc pool size in infants is related to key variables of zinc homeostasis. In: Journal of Nutrition. 2003 ; Vol. 133, No. 5 SUPPL. 2.
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